Short-course antibiotics after appendectomy for complicated appendicitis show similar infection risk to long-course therapy
Short-course antibiotics after complicated appendectomy show similar infection risk to longer courses
A meta-analysis of 3251 patients from 4 RCTs and 9 observational studies found short-course antibiotic therapy (<3 days) after appendectomy …
Shorter antibiotics after complicated appendectomy carry similar infection risks to longer courses while often shortening hospital stays.
Linezolid vs clindamycin shows no ICU or hospital stay difference in severe SSTIs
For severe skin infections, does one antibiotic keep you out of the hospital longer?
A systematic review and meta-analysis of patients with severe or necrotizing skin and soft tissue infections found no significant difference…
For severe skin infections, using linezolid instead of clindamycin does not help patients leave the hospital faster, though it may lower kid…
Meta-analysis finds no mortality difference between CA and CT for drug-resistant P. aeruginosa infections
Which antibiotic works better for dangerous drug-resistant infections?
A meta-analysis of 10 observational studies including 1409 patients with drug-resistant P.
Two powerful new antibiotics show equal survival rates for patients fighting dangerous, drug-resistant infections.
Meta-analysis finds no significant difference in outcomes between high- and low-dose ceftriaxone for non-CNS infections
Do higher doses of a common antibiotic help adults with infections?
A meta-analysis of eight studies involving 5145 adults with non-CNS infections found no statistically significant difference in clinical cur…
Higher doses of the antibiotic ceftriaxone show no clear benefit over the standard 1-gram daily dose for curing infections in adults, based …
Meta-analysis finds 30.7% molecular prevalence of yellow fever virus in non-human primates
Yellow fever virus found in many monkeys in the Americas, study shows
A meta-analysis of 39 studies involving 7,183 non-human primates found pooled molecular prevalence of yellow fever virus infection was 30.7%…
Yellow fever virus was found in 31% of monkey samples and 43% of tissue tests, with infected animals in detailed cases all dying from severe…
Short-course antibiotic therapy shows comparable outcomes to extended courses in ICU patients with MDR Gram-negative infections
Can critically ill patients safely take shorter courses of powerful antibiotics?
A meta-analysis of 602 critically ill ICU patients found no significant difference in mortality or clinical failure between short-course (6-…
Critically ill patients with tough infections may safely take shorter antibiotic courses, though relapse risk warrants further study.
Network meta-analysis suggests Chinese patent medicines plus Western medicine may improve functional constipation in elderly
Chinese herbal medicines combined with Western drugs may help elderly constipation
A network meta-analysis of 23 RCTs involving 2065 elderly patients with functional constipation found that six Chinese patent medicines comb…
Adding specific Chinese herbal medicines to standard Western drugs may improve overall treatment response for elderly constipation, though e…
Review: New syphilis tests bridge diagnostic window but face standardization hurdles
New syphilis tests show promise for earlier detection but face standardization hurdles
A systematic review synthesizes evidence on technological innovations for syphilis diagnosis.
New syphilis tests could detect infections earlier than traditional methods, but global standardization hurdles remain before they can be wi…
Engineered bacteriophage systems show potential framework for treating multidrug-resistant bacterial infections
Can engineered viruses help fight superbugs? A new review maps a path forward
A systematic review discusses advances in engineered bacteriophage therapeutic systems for multidrug-resistant pathogens.
Engineered viruses paired with advanced imaging offer a new way to fight dangerous superbugs that no longer respond to standard antibiotics.
Systematic review examines PI3K/Akt-mTOR pathway role in host defense and pathogen evasion
How do germs outsmart our immune system? A key cellular pathway holds clues
A systematic review synthesizes research on the PI3K/Akt-mTOR signaling pathway in infectious diseases.
Our immune system fights infection by activating a key cellular switch, but clever germs hijack the same control panel to hide and survive i…
Systematic review details metabolic adaptations of intracellular bacterial pathogens within host cells
How do bacteria hide inside our cells to survive and cause disease?
A systematic review synthesized evidence on how intracellular bacterial pathogens, including Listeria and Chlamydia species, employ sophisti…
Bacteria like Listeria and Chlamydia act as metabolic thieves, stealing nutrients from our cells to hide from our immune system and survive.
Meta-analysis finds endothelial swelling and plasma cell infiltration common in secondary syphilis histology
What do syphilis skin lesions look like under the microscope? A new review finds patterns
A systematic review and meta-analysis of eight studies involving 384 patients with secondary syphilis found endothelial swelling (85% preval…
When blood tests or rashes aren't clear, doctors use skin biopsies to spot swelling in tiny blood vessels and dense white blood cell cluster…