Efficacy of Intravenous Thrombolysis for Acute Ischemic Stroke Patients Late in Window
Thrombolytic drugs improve recovery for patients with late ischemic stroke
Meta-analysis confirms that IV thrombolysis improves functional outcomes in patients presenting 4.5 to 24 hours after stroke onset without i…
Patients with a stroke between 4.5 and 24 hours after symptoms can see better recovery with certain clot-busting medications.
eSMARTER digital platform meets non-inferiority goals for Alzheimer's genetic and biomarker result disclosure
Digital Platforms Match Clinician Support for Alzheimer's Genetic Results
This randomized non-inferiority trial of 651 adults with Alzheimer's disease found that the eSMARTER digital platform was non-inferior to cl…
A new digital platform provides a scalable way to share Alzheimer's genetic results while maintaining patient well-being and knowledge.
No-reflow phenomenon affects at least 25% of patients after reperfusion in acute ischemic stroke
Small blood vessel blockages hinder recovery after a major stroke
This narrative review examines the no-refure phenomenon in acute ischemic stroke, noting it affects at least 25% of patients after reperfusi…
Even after doctors open a large blocked artery, tiny blood vessel issues can stop blood from reaching damaged brain tissue in at least 25% o…
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage
Pressure controlled irrigation may reduce brain damage after brain bleeds
Meta-analysis suggests pressure-controlled active CSF irrigation significantly reduces the odds of delayed cerebral infarction and symptomat…
A review of over 2,000 cases suggests that pressure-controlled irrigation can lower the risk of brain tissue death after a ruptured aneurysm…
Tenecteplase shows higher mRS 0 to 1 rates in distal M3 and beyond occlusions
Trial shows tenecteplase may help specific types of stroke
This secondary analysis of a randomized clinical trial involved 492 patients with perfusion imaging-confirmed stroke within 4.5 hours of sym…
A secondary analysis suggests tenecteplase may lead to better outcomes for patients with specific types of stroke compared to alteplase.
Stroke prevalence 14% after LVAD, highest in Asia, projected to decline
Stroke rates for heart failure patients with LVAD devices vary by region
This meta-analysis of 132,869 patients across 16 countries found a global post-LVAD stroke prevalence of 14.0% (95% CI 12.0-15.0%), with Asi…
Stroke risk for heart failure patients with LVAD devices varies by region, with higher rates seen in Asia compared to North America.
Slowly expanding lesions occur in 78% of patients with Multiple Sclerosis
New data shows common types of lesions in Multiple Sclerosis
This meta-analysis of 4,786 patients with Multiple Sclerosis identifies the prevalence and volume of slowly expanding lesions (SELs) and par…
A large study of over 4,000 people with Multiple Sclerosis identifies common patterns in brain lesions to help understand the disease.
Organochlorine pesticide exposure is associated with a 2.19 odds ratio for Alzheimer's disease risk
Pesticide exposure linked to higher risk of Alzheimer's disease
This meta-analysis of human studies indicates a significant positive association between organochlorine pesticide (OCP) exposure and Alzheim…
New data shows a strong link between organochlorine pesticides and Alzheimer's disease, highlighting the impact of environmental toxins on b…
Curcumin and resveratrol show selective signals for modulating neuroinflammation and microglial inflammatory signaling
Curcumin and Resveratrol Show Mixed Results for Brain Inflammation
This narrative review examines the role of curcumin, resveratrol, and plant-rich dietary patterns in modulating neuroinflammation and microg…
New research looks at how plant compounds like curcumin and resveratrol might affect brain inflammation and cognitive health.
Intravenous tirofiban before endovascular treatment increases risk of parenchymal hematoma type 2
Trial shows tirofiban increases bleeding risk in some stroke patients
This randomized controlled trial of 945 patients with acute large vessel occlusion of the anterior circulation found that intravenous tirofi…
A large trial found that using tirofiban before certain stroke treatments may increase the risk of specific types of brain bleeding.
Smoking is not significantly associated with disability progression in patients with multiple sclerosis
Smoking and disability progression in multiple sclerosis patients
This meta-analysis investigated the association between smoking and disability progression in patients with multiple sclerosis. The analysis…
New data looks at how smoking affects disability for people with multiple sclerosis, finding no clear link to specific disability scores.
Clopidogrel plus aspirin for 21 days provides favorable net clinical benefit in minor ischemic stroke
Dual antiplatelet therapy shows mixed results for stroke prevention
This Bayesian network meta-analysis of 8 trials involving 50,349 adults with minor ischemic stroke or high-risk TIA found that clopidogrel p…
New data compares different blood thinner combinations to find the best way to prevent a second stroke after a minor medical emergency.