Oral cladribine reshapes CSF immune cell composition in relapsing multiple sclerosis
Cladribine therapy changes immune cells in fluid from the brain in a small MS study
This single-site phase IV clinical trial used single-cell sequencing on CSF and blood from 13 individuals with relapsing MS before and after…
Cladribine therapy reshapes immune cells in the brain's fluid by reducing harmful memory B cells while boosting protective Treg cells in mul…
Protocol for pilot RCT of neuromodulation-augmented balance training in ambulatory people with multiple sclerosis
New Balance Trick Helps MS Walkers Move Better
This published protocol describes a pilot randomized trial evaluating the feasibility, acceptability, safety, and preliminary clinical effic…
This new approach combines simple exercises with gentle electrical signals to help people with multiple sclerosis walk more confidently.
Elevated monocyte-to-HDL ratio associated with stroke predisposition in U.S. adults
High monocyte-to-HDL cholesterol ratio linked to higher stroke risk in adults
This cross-sectional study of 43,321 U.S.
High monocyte-to-HDL cholesterol ratios are linked to a higher risk of stroke in U.S. adults, based on data from over 43,000 people.
Tenecteplase shows worse functional outcomes in older patients with minor ischemic stroke compared to standard care
The Clot-Busting Drug That Backfires in Patients Over 80
This post hoc analysis of a randomized controlled trial evaluated tenecteplase versus nonthrombolytic standard of care in 884 patients with …
In patients over 80 with minor stroke, a clot-busting drug improved short-term recovery but worsened outcomes at 90 days compared to standar…
MRI outcomes show weak association with disability in primary progressive multiple sclerosis patients
MRI results show weak connection to disability changes in progressive multiple sclerosis
This Phase 3 trial secondary analysis evaluated 943 patients with primary progressive multiple sclerosis treated with glatiramer acetate ove…
MRI scans show weak links to disability changes in progressive multiple sclerosis, challenging their use as reliable trial endpoints for thi…
6-week multimodal exercise training feasible for frail people with multiple sclerosis in pilot RCT
Exercise Helps Frail MS Patients Feel Better
This pilot randomized controlled trial in 16 frail people with multiple sclerosis tested a 6-week multimodal exercise program versus waitlis…
A new exercise program combining virtual reality and resistance training helps frail people with multiple sclerosis feel better and move mor…
Rapid EEG and AI may aid early recognition of status epilepticus in emergency and prehospital settings
Faster Brain Scans May Stop Hidden Seizures Before Damage
This narrative review examines the use of rapid electroencephalography (EEG) augmented by artificial intelligence for detecting status epile…
New rapid brain scans using AI can spot hidden seizures that cause confusion or coma, helping doctors treat patients faster before permanent…
Meta-analysis finds respiratory muscle training improves some lung function measures in multiple sclerosis
Breathing Easier: New Hope for MS Patients
This systematic review and meta-analysis of 249 patients with multiple sclerosis synthesizes evidence on respiratory muscle training.
Breathing exercises strengthen chest muscles and improve airflow for people with Multiple Sclerosis who struggle to take a full breath.
VerifyNow-guided antiplatelet modification linked to lower stroke recurrence in atherothrombotic or lacunar infarction
Testing Blood Saves Stroke Patients From Recurrence
A retrospective observational study of 243 patients with atherothrombotic or lacunar infarction found that VerifyNow-guided antiplatelet the…
Doctors who adjusted blood thinner choices based on a simple blood test saw far fewer repeat strokes in patients with prior clots.
Systematic review summarizes complement system alterations in Alzheimer's disease pathogenesis and therapeutic potential
Could a hidden immune response be driving Alzheimer's disease?
This systematic review evaluates the role of complement system alterations in Alzheimer's disease.
A hidden immune system error called the complement system may drive excessive brain connection loss and inflammation in Alzheimer's disease.
Qihuang needle therapy protocol for Parkinson's disease in 69 patients
Parkinson's Treatment Gets a New Brain Scan
This is a randomized controlled trial protocol for 69 Parkinson's disease patients, comparing Qihuang needle therapy to verum acupuncture, s…
Advanced brain scans reveal how a new needle therapy changes Parkinson's brain activity to help patients move better and feel less pain.
Network meta-analysis finds muscle energy technique superior for pain in chronic neck pain
Stuck With Neck Pain? This Simple Therapy May Beat Drugs
A network meta-analysis of 1,224 patients with chronic nonspecific neck pain compared different exercise therapies to conventional exercise …
A gentle, targeted muscle therapy appears to ease chronic neck pain better than the go-to exercises most clinics offer today.