Envafolimab plus lenvatinib and capecitabine shows activity in resected biliary tract cancer
Combination therapy shows promise for preventing biliary tract cancer recurrence after surgery
A single-arm phase II trial in 28 patients with resected biliary tract cancer at high risk of recurrence found median disease-free survival …
A new three-drug combination helped 68% of high-risk biliary tract cancer patients stay cancer-free for a year after surgery, with 91% still…
Hypoxia in solid tumors drives metabolic reprogramming, immune suppression, and therapeutic resistance
How do tumors survive in low oxygen? They completely change how they eat.
A systematic review synthesizing evidence on hypoxia in solid tumors found that low oxygen tension orchestrates metabolic reprogramming thro…
When tumors run out of oxygen, they switch diets to eat fat and glutamine, becoming more invasive, acidic, and resistant to treatment.
FDA Approves Focinvez (fosaprepitant) for Prevention of Chemotherapy-Induced Nausea and Vomiting
FDA approves a new intravenous drug to help prevent nausea and vomiting from chemotherapy.
The FDA has approved Focinvez, a substance P/NK1 receptor antagonist, for the prevention of acute and delayed nausea and vomiting associated…
FDA approves new IV drug to prevent severe nausea and vomiting from chemotherapy in adults and children 6 months and older.
Larger baseline tumor burden linked to shorter OS in rare cancers treated with nivolumab plus ipilimumab
Does tumor size predict how well immunotherapy works for rare cancers?
A secondary analysis of a phase 2 basket trial in 722 patients with rare/ultrarare malignancies found that larger baseline tumor burden was …
For rare cancers treated with immunotherapy, larger tumors at the start were linked to shorter overall survival, but not to how long patient…
Phase 2 trial links early monocyte elevation to response in gastric cancer immunotherapy
Small study finds immune cell changes linked to better response in gastric cancer treatment
A phase 2 trial in 24 patients with metastatic gastric cancer receiving first-line pembrolizumab plus XELOX found that early elevation of ci…
Patients with metastatic gastric cancer who saw early immune cell changes in their blood were more likely to survive longer while receiving …
VLSM analysis of 350 meningioma resections links tumor location to histology, symptoms, and surgical outcomes.
Brain tumor location patterns linked to symptoms and surgical outcomes in study
A retrospective, single-center cohort of 350 patients who underwent meningioma resection found that voxel-based lesion symptom mapping (VLSM…
Brain tumor location in the brain is linked to specific symptoms and how well surgery removes the growth, according to a new study.
Feasibility trial shows ePRO-led survivorship care may improve symptoms in early-stage cancer patients
Digital symptom tracking shows promise for cancer survivors in early trial
A feasibility RCT of 200 women with early-stage breast or gynecologic cancer tested a 12-month ePRO-led multidisciplinary intervention versu…
A digital health program helped recent cancer survivors in Ireland report less fatigue, anxiety, and depression while improving their qualit…
Corticosteroid therapy associated with greater weight loss and poorer appetite in advanced pancreatic cancer
Corticosteroid therapy linked to more weight loss in advanced pancreatic cancer patients
A post hoc analysis of the MISTRAL trial in 244 patients with advanced pancreatic cancer found corticosteroid therapy was associated with gr…
Corticosteroid therapy linked to more weight loss in advanced pancreatic cancer patients, who also reported less appetite and lower BMI duri…
Meta-analysis: Preoperative calcitonin predicts lateral cervical lymph node metastasis in medullary thyroid carcinoma
Can a simple blood test help surgeons plan thyroid cancer operations?
A meta-analysis of 8 studies (951 patients) with medullary thyroid carcinoma found preoperative serum calcitonin demonstrated good diagnosti…
A simple blood test measuring calcitonin levels can accurately predict if medullary thyroid cancer has spread to neck lymph nodes before sur…
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Review summarizes molecular pathways and treatment options for Adult T-cell leukemia/lymphoma
What helps patients with a rare, aggressive blood cancer?
A systematic review summarizes the molecular pathogenesis and treatment landscape for Adult T-cell leukemia/lymphoma (ATLL). The review note…
For patients with rare, aggressive Adult T-cell leukemia/lymphoma, a drug called mogamulizumab shows promise when standard treatments fail.
Survey finds 67% of U.S. adults aged 50-75 met colorectal cancer screening recommendations
Survey finds about two-thirds of eligible U.S. adults are up to date on colon cancer screening
A 2018 observational survey of U.S. adults aged 50-75 found 67.0% met USPSTF colorectal cancer screening recommendations, and 60.6% reported…
About two-thirds of eligible U.S. adults aged 50 to 75 were up to date on colon cancer screening, yet a gap remains for many people.