Ambulatory hypertension in pediatric chronic kidney disease patients increases risk of left ventricular hypertrophy
High Blood Pressure Linked to Heart Changes in Children
This meta-analysis of 51 studies involving 6509 children with chronic kidney disease found that ambulatory hypertension is associated with i…
New data shows a strong link between high blood pressure and heart muscle thickening in children with chronic kidney disease.
Congenital cytomegalovirus is associated with a 10-fold increased risk of vestibular changes in children
Children with congenital cytomegalovirus face higher risk of balance issues
This meta-analysis of 8 observational studies examined the association between congenital cytomegalovirus (cCMV) and vestibular outcomes in …
Children born with a specific virus may face much higher risks for inner ear and balance problems, though more research is needed to confirm…
NICU noise levels frequently exceed recommended limits and primarily originate from alarms and respiratory devices
NICU noise levels often exceed safety limits for preterm infants
This systematic review of 113 studies identifies alarm systems and respiratory support as primary sources of high-level noise in NICUs. Whil…
Most neonatal intensive care units have noise levels much higher than recommended, especially from alarms and breathing equipment.
MIRAGE syndrome in a neonate: SAMD9 mutation links 46,XY DSD with multisystem features
Rare syndrome identified in newborn with female genitalia and XY chromosomes
This case report with literature review describes a male neonate with 46,XY karyotype and female external genitalia who was diagnosed with M…
A newborn with female genitals but male chromosomes was found to have MIRAGE syndrome, a rare genetic disorder linked to SAMD9 mutations.
Sabin-strain inactivated poliovirus vaccine provides immunogenicity comparable to Salk-strain inactivated poliovirus vaccine
Sabin Strain Vaccine Shows Comparable Protection Against Polio
This systematic review and meta-analysis of 4646 infants found that Sabin-strain inactivated poliovirus vaccine (sIPV) yields seroconversion…
New analysis shows the Sabin-strain vaccine provides similar protection against polio as the Salk-strain for infants, supporting global heal…
Reduced-dose craniospinal radiation and smaller volume boost for medulloblastoma patients
Trial Shows Reduced Radiation May Help Children With Medulloblastoma
This randomized phase 3 trial evaluated reduced-dose craniospinal radiation (18.00 Gy) and a smaller volume boost in children aged 3 to 7 wi…
A large clinical trial looked at whether reducing radiation doses for children with medulloblastoma can maintain safety and effectiveness.
Multimodal therapy and targeted inhibitors show modest activity for pediatric malignant rhabdoid tumor of the kidney
New Targeted Therapies Show Potential for Rare Kidney Tumors
This mini review examines multimodal therapies, EZH2 inhibition, and CDK4/6 blockade for pediatric patients with malignant rhabdoid tumor of…
Targeted treatments like EZH2 and CDK4/6 inhibitors may offer new options for children with a rare type of kidney cancer.
Aprotinin and tranexamic acid show varying efficacy for hemostasis in neonatal cardiac surgery
Trial Shows Aprotinin May Reduce Blood Loss in Infant Heart Surgery
This network meta-analysis of 27 studies involving 4,556 patients evaluated various hemostatic strategies in neonatal and infant cardiac sur…
A large review of 4,556 patients suggests aprotinin may be more effective than other treatments for managing blood loss during infant heart …
Deferred single-stage surgical intervention is a safe option for repairing omphalocele with congenital stoma
Surgical Repair Options for Omphalocele with Congenital Stoma
This scoping review and case report examine the management of neonates with omphalocele associated with a congenital stoma. The authors sugg…
A new look at surgical options shows that some infants with omphalocele and a congenital stoma may benefit from specific staged repair metho…
Interrupted suturing shows no significant difference from continuous suturing in TIP urethroplasty for hypospadias
Suturing technique does not affect hypospadias surgery outcomes
This systematic review and meta-analysis of 2,625 patients compared interrupted and continuous suturing techniques during tubularised incise…
For boys having hypospadias repair, interrupted and continuous suturing lead to similar complication rates, a new analysis finds.
Fluconazole resolves pulmonary cryptococcosis in immunocompetent adolescent
Fluconazole treats lung infection in a healthy 14-year-old girl
This case report and literature review describes a 14-year-old immunocompetent girl with pulmonary cryptococcosis who was successfully treat…
A rare lung infection caused by fungus can occur in children without weakened immune systems, and fluconazole treatment showed success.
POCUS-assisted catheterization increases first-attempt success to 89.7% versus 72.5% in children under 36 months
Ultrasound guidance boosts first-attempt success for catheters in young children
This systematic review and meta-analysis evaluated real-time POCUS-assisted urethral catheterization versus standard blind techniques in chi…
Using ultrasound guidance during catheterization in young children significantly increased first-attempt success and reduced dry taps compar…