Retrospective analysis of PEW diagnosis prevalence and correlates in children with CKD stages 3-5D
Why Children With Kidney Disease Are Quietly Losing Muscle and Weight
This observational cohort study from Beijing Children's Hospital retrospectively analyzed 170 children with CKD stages 3-5D to assess the pr…
Over half of children with advanced kidney disease show signs of dangerous malnutrition, often missed until growth slows and weight drops.
In silico analysis compares HIV-1 ENV CD8+ T cell epitopes restricted by HLA alleles A*01:01 and B*07:02 against bNAb targets
Why Your Body's Best Defense Might Be a Team Effort
This in silico analysis and literature review evaluated 1820 HIV-1 ENV peptides overlapping clades A and D.
A genetic marker linked to slower HIV infection triggers fewer T cell responses, suggesting quality matters more than quantity in immune def…
Gender-affirming hormone and puberty blocker use increased in Norway from 2008 to 2022
Norway saw increased use of gender-affirming hormones and blockers since 2015
A nationwide register-based study in Norway from 2008 to 2022 found that incidence of gender incongruence diagnoses and prevalence of gender…
Since 2015, more teens in Norway received gender-affirming hormones and puberty blockers, while diagnoses for gastrointestinal issues also r…
FDA Approves Beyfortus (nirsevimab-alip) for Prevention of RSV Lower Respiratory Tract Disease in Neonates and Infants
FDA approves new drug called Beyfortus to help protect babies and young children from serious RSV illness
Beyfortus is approved for preventing RSV lower respiratory tract disease in neonates and infants during their first RSV season, and in child…
FDA approves Beyfortus to prevent serious RSV illness in newborns and infants during their first season and children up to 2 years old in th…
Pelvic floor physiotherapy improves quality of life and reduces painful defecation in pediatric functional constipation
When Laxatives Are Not Enough, This Therapy May Help Kids
This meta-analysis of seven randomized controlled trials involving 775 pediatric and adolescent participants assessed pelvic floor physiothe…
For children whose constipation will not budge on laxatives alone, targeted pelvic floor therapy eased pain and boosted quality of life acro…
Managed transition increased AMHS care receipt and appropriate transitions at 15 months in youth with IQ ≤70
A Better Bridge from Teen to Adult Mental Health Care Cuts Dropout in Half
This cluster randomised clinical trial secondary analysis involved 793 participants receiving CAMHS care with IQ ≤70 near their service tran…
A planned handoff between teen and adult mental health services nearly doubled the share of young people who successfully moved to adult car…
PRS research shows 21.6% annual growth, projected to mature by 2026, with concentrated funding and geography
Genetic Risk Scores Are Booming, but Most Patients Still Aren't Represented
A systematic bibliometric review of 10,269 polygenic risk score (PRS) publications from 1999 to 2024 found strong annual growth (21.56%) and…
Polygenic risk scores are booming, yet research remains concentrated in a few countries, leaving most of the world's population underreprese…
Concurrent training improves fitness in youth compared to isolated strength or endurance training
Mixing Weights and Cardio May Supercharge Kids' Fitness
A meta-analysis of children and adolescents aged 10-24 years found that 8-week concurrent training significantly enhanced lower-body explosi…
Young athletes who mix weightlifting with running in the same session gain more fitness than those who stick to just one.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Study protocol assesses multimodal activity intervention versus hospital-only activity on gross motor function in preschool children with cancer
A Simple Play Program Could Protect Young Brains During Cancer Treatment
This study protocol outlines a randomized controlled trial involving 82 preschool children (aged 1–5 years) newly diagnosed with cancer.
A simple play program could protect young brains during cancer treatment by helping preschoolers aged 1 to 5 keep growing and learning while…
Visual biofeedback shows faster early progress than motor-based therapy for children with residual speech sound disorder
Why Some Kids Finally Nail the "R" Sound Faster
In a randomized controlled trial of 108 children aged 9-15 years with residual speech sound disorder affecting American English /ɹ/, visual …
For kids who have worked on the R sound for years with little progress, seeing their tongue on a screen helped them learn faster than words-…
Oral melatonin adjunct therapy improves echocardiographic parameters and clinical outcomes in neonates with persistent pulmonary hypertension of the newborn
Could The Sleep Hormone Help Newborn Hearts Heal Faster?
This randomized controlled trial evaluated oral melatonin added to standard therapy versus standard therapy alone in 80 neonates with persis…
Adding melatonin to standard care helped newborn hearts pump stronger and got babies off ventilators sooner in a careful 80-baby trial.