Phase 4
Completed N=43
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
Source: ClinicalTrials.gov NCT00158262 ↗Enrolled (actual)
43
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Mental Imagery at Month 1 — 40.7; 33.7 percent probability
◆ Published Evidence
Highly cited
173citations · ~12 / year
Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery.
Summary
This study will assess the effectiveness of taking propranolol soon after a traumatizing incident in reducing the incidence and severity of posttraumatic stress disorder in acutely traumatized individuals.
Linked Publications (3)
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Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery.
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Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
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Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Mental Imagery at Month 1 |
40.7; 33.7 | — |
| PRIMARY Physiological Posterior Probability of PTSD as Determined From Psychophysiologic Responses During Script-Driven Mental Imagery at Month 3 |
34.9; 32.0 | — |
| SECONDARY Clinician-Administered PTSD Scale (CAPS) Total Score |
28.5; 28.5; 19.0; 21.2 | — |
Eligibility Criteria
Inclusion Criteria
- Experienced an acute psychological traumatic event
- Heart rate of 80 beats per minute (bpm) or greater
- Understands English
Exclusion Criteria
- Traumatic event that occurred more than four hours before arrival to emergency department
- Physical injury that may affect safe participation (e.g., head injury)
- Systolic blood pressure less than 100 mm Hg
- Medical or surgical condition that poses a risk of shock
- Medical condition that may affect the safe administration of propranolol
- Previous adverse reaction to, or non-compliance with, a beta-blocker
- Current use of medication that may react badly with propranolol
- Elevated saliva alcohol level
- Presence of salivary opiates, marijuana, cocaine, or amphetamines
- Pregnant or breastfeeding
- Traumatic event reflecting ongoing victimization
- Psychiatric condition that may affect safe participation
- Unwilling or unable to commute to Boston for research visits
- Attending physician in emergency department does not advise participation
Data sourced from ClinicalTrials.gov (NCT00158262) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.