A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia
Summary
Linked Publications (2)
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Antepartum treatment without early cordocentesis for standard-risk alloimmune thrombocytopenia: a randomized controlled trial.
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Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Newborns With a Birth Platelet Count > 50,000/uL |
48; 47 | — |
| SECONDARY Intracranial Hemorrhage: Number Occurring in Fetuses and Newborns of Mothers in Study |
0; 0 | — |
| SECONDARY Number of Fetal Platelet Counts > 50,000/uL |
44; 43 | — |
Eligibility Criteria
Inclusion Criteria
Pregnant women are eligible for inclusion into the Very High Risk Group if they:
- are PLA-1 (platelet antigen A1) negative and have known platelet incompatibility with their fetus
- have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks gestation (as best as could be estimated)
- are less than 19 weeks gestation
Pregnant women are eligible for inclusion into the High Risk Group if they:
- are PLA-1 negative and have known platelet incompatibility with the fetus
- have had a previous child who suffered an antenatal hemorrhage after 28 weeks gestation (as best as could be estimated)
- are between 12-30 weeks gestation
Pregnant women are eligible for inclusion into the Standard Risk Group if they:
- are PLA-1 negative and have known platelet incompatibility with the fetus
- have not had a previous child who suffered an antenatal hemorrhage
- are between 20-30 weeks gestation
Exclusion Criteria
Women are not eligible for inclusion into the Very High Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage after 28 weeks gestation
- are greater than 19 weeks gestation
Women are not eligible for inclusion into the High Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks gestation
- are greater than 30 weeks gestation
Women are not eligible for inclusion into the Standard Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage
- are greater than 30 weeks gestation
Data sourced from ClinicalTrials.gov (NCT00194987) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.