N/A
Completed N=105
Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1
Source: ClinicalTrials.gov NCT00218439 ↗Enrolled (actual)
105
Serious AEs
0.0%
Results posted
May 2014
Primary outcomePrimary: Systolic Blood Pressure Response to Stress — 16.85; 11.71 mmHg — p=<0.001
Summary
Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other measures of stress response. This combination may result in greater cardiovascular harm than either smoking or stress alone. The purpose of this study is to determine the effects of paroxetine on the response to stress after smoking.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Systolic Blood Pressure Response to Stress |
16.85; 11.71 | <0.001 sig |
Eligibility Criteria
Inclusion Criteria
- Smokes an average of at least 10 cigarettes per day during the year prior to enrollment
Exclusion Criteria
- Interested in quitting smoking within the 3 months following enrollment
- Current unstable medical condition
- Substance abuse within the year prior to enrollment
- Current use of any medications (e.g., psychoactive medications, antihypertensives) that, in the opinion of the investigators, might interfere with study measures or that would be expected to interact with paroxetine (e.g., CYP2D6 substrates)
- Smoking cessation therapy within the 3 months prior to enrollment
- Regular use of any form of tobacco other than cigarettes
- Significant psychiatric disorders as assessed by the PRIME-MD and verified by a clinician
- History of hypersensitivity to any selective serotonin reuptake inhibitor
- Pregnancy or breastfeeding
Data sourced from ClinicalTrials.gov (NCT00218439). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.