Phase 1
Completed N=14
Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Infant Respiratory Distress Syndrome · Respiratory Insufficiency · Apnea of Prematurity
Source: ClinicalTrials.gov NCT00296231 ↗
Enrolled (actual)
14
Serious AEs
0.0%
Results posted
Dec 2010
Primary outcomePrimary: pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values — 50; 45 mm Hg — p=0.011
Summary
The purpose of this study is to test whether application of high frequency ventilation through a nasal tube can lower blood carbon dioxide levels in stable preterm infants.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values |
50; 45 | 0.011 sig |
| SECONDARY Transcutaneous CO2 Measurements as a Trend Throughout Intervention |
47; 46 | — |
Eligibility Criteria
Inclusion Criteria
- birthweight less than 1500 g
- Age >7 days
- Free of severe intraventricular hemorrhage (Grade III-IV)
- requiring nasal continuous positive airway pressure with a stable compensated respiratory acidosis (pH 7.25 - 7.45, pCO2 > 43 mm Hg),
- medically stable.
Exclusion Criteria
- major congenital anomalies
Data sourced from ClinicalTrials.gov (NCT00296231). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.