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Phase 3 Completed N=75 Randomized Triple-blind Treatment

Efficacy of Lansoprazole in Chronic Post Nasal Drip

Larynx Disease
Source: ClinicalTrials.gov NCT00335283 ↗
Enrolled (actual)
75
Serious AEs
0.0%
Results posted
Aug 2012
Primary outcomePrimary: Post Nasal Drainage Symptom Response — 55; 3.5; 50; 5 Scores on a Scale — p=.01

Summary

The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on clinical and physiologic parameters.

Outcome Measures

OutcomeResultp-value
PRIMARY
Post Nasal Drainage Symptom Response		 55; 3.5; 50; 5 .01 sig
SECONDARY
Rhinosinusitis Outcome Measure(RSOM-31)		 63; 51; 40; 36; 35; 35 .97
SECONDARY
Sino Nasal Outcome Test (SNOT-20)		 36; 35; 25; 32; 20; 27 .06
SECONDARY
Quality of Life Questionnaire (QOLRAD)		 155; 160; 174; 155; 173; 160 .006 sig

Eligibility Criteria

Inclusion Criteria

  • Negative RAST inhalant allergy panel OR negative skin testing (Group A)
  • Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B)
  • Allergen avoidance
  • Topical nasal steroids
  • Allergy shots if indicated
  • Antihistamines
  • Negative CT sinuses (coronal)
  • < 4mm of mucosal thickening and < 3 sinus sites
  • Absence of air-fluid levels
  • Negative anterior rhinoscopy
  • Absence of pus, crusts on mucosal surfaces

Exclusion Criteria

  • Age < 18
  • Pregnancy, confirmed by urine pregnancy test at day of randomization
  • Ciliary dyskinesia
  • Immune deficiency
  • Cystic fibrosis
  • Diagnosis of acute sinusitis or chronic RS (AAO-HNS)
  • Active use of topical decongestant
  • Use of PPI within the last 30 days
  • Previous fundoplication
  • Uncontrolled thyroid disease
  • Isolated chronic cough without the symptom of post nasal drip
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00335283). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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