Phase 1 N=99 Randomized Double-blind Treatment

CBT With Disulfiram and Contingency Management

Cocaine Abuse

Bottom Line

View on ClinicalTrials.gov: NCT00350870 ↗

Enrolled (actual)

Serious AEs

34.3%

Results posted

Dec 2014

Primary outcome: Primary: Change in Cocaine Use by Self Report — 72.2; 79.2; 91.1; 69.6 percentage of days abstinent

Study Design & Population

Study type: Interventional
Phase: Phase 1
Interventions: disulfiram (Drug); Placebo (Drug); Placebo plus Contingency Management (Behavioral); Disulfiram plus Contingency Management (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Yale University
Primary completion: Dec 2010

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Cocaine Use by Self Report	72.2; 79.2; 91.1; 69.6	—
PRIMARY Change in Cocaine Use by Urine Toxicology Results	17.9; 30.1; 53; 42.6	—

Summary

This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

Eligibility Criteria

Inclusion Criteria

18-50 year old
cocaine dependent
willing to sign consent
willing to accept randomization to intervention

Exclusion Criteria

significant medical conditions
psychiatric disorder with current use of prescribed psychotropic medication
lifetime schizophrenia or bipolar disorder
suicidality or homicidality
unlikely to be able to complete 1 year follow up
unable to speak or read English at a third grade level

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00350870). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.