Phase 1
Completed N=99
CBT With Disulfiram and Contingency Management
Cocaine Abuse
Source: ClinicalTrials.gov NCT00350870 ↗
Enrolled (actual)
99
Serious AEs
34.3%
Results posted
Dec 2014
Primary outcomePrimary: Change in Cocaine Use by Self Report — 72.2; 79.2; 91.1; 69.6 percentage of days abstinent
Summary
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Cocaine Use by Self Report |
72.2; 79.2; 91.1; 69.6 | — |
| PRIMARY Change in Cocaine Use by Urine Toxicology Results |
17.9; 30.1; 53; 42.6 | — |
Eligibility Criteria
Inclusion Criteria
- 18-50 year old
- cocaine dependent
- willing to sign consent
- willing to accept randomization to intervention
Exclusion Criteria
- significant medical conditions
- psychiatric disorder with current use of prescribed psychotropic medication
- lifetime schizophrenia or bipolar disorder
- suicidality or homicidality
- unlikely to be able to complete 1 year follow up
- unable to speak or read English at a third grade level
Data sourced from ClinicalTrials.gov (NCT00350870). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.