Phase 4
Completed N=420
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Intubation
Source: ClinicalTrials.gov NCT00355368 ↗
Enrolled (actual)
420
Serious AEs
0.0%
Results posted
Dec 2011
Primary outcomePrimary: Number of Participants Exhibiting Desaturation >5% — 73; 66 participants
Summary
Emergency intubation of patients in intensive care is a high-risk endeavour. For many decades, succinylcholine has been the neuromuscular blocking agent of choice. However, succinylcholine may have life-threatening side effects and is contraindicated in a variety of diseases relevant in intensive care. The nondepolarizing agent rocuronium has been propagated as alternative for succinylcholine. Though a recent meta-analysis found no difference in intubating conditions between succinylcholine and rocuronium in elective cases, there are no data in emergent cases in intensive care. The aim of the present study is to compare succinylcholine and rocuronium with regard to 1) quality of intubating conditions, 2) length of the intubating sequence, 3) failed intubating attempts, 4) hemodynamic sequelae of intubation, and 5) desaturations.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Exhibiting Desaturation >5% |
73; 66 | — |
| SECONDARY Haemodynamic Sequelae of Intubation |
— | — |
| SECONDARY Time to Completion of Intubation |
81; 95 | — |
| SECONDARY Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. |
8.3; 8.2 | — |
| SECONDARY Number of Participants With an Failed First Intubation Attempts |
32; 36 | — |
Eligibility Criteria
Inclusion Criteria
- indication for emergency intubation in intensive care
- availability of qualified study physician
Exclusion Criteria
- contraindication against succinylcholine or rocuronium
- indication for awake fibreoptic intubation
Data sourced from ClinicalTrials.gov (NCT00355368). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.