Phase 4
Completed N=41
Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production
Source: ClinicalTrials.gov NCT00361712 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Mar 2018
Primary outcomePrimary: Maternal Cytokine IL-10 Levels of pg/ml Upon Enrollment — 12.7; 14.2 pg/ml
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
During labor there is an increased production of inflammatory mediators called cytokines. Higher concentration of certain cytokines has been linked to adverse neonatal and maternal outcomes.
Epidural analgesia is commonly performed after the parturient feels labor pain.
We hypothesis that preemptive epidural analgesia (initiated before labor pain begins)can influence the production of cytokines.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maternal Cytokine IL-10 Levels of pg/ml Upon Enrollment |
12.7; 14.2 | — |
| PRIMARY Maternal Cytokine of pg/ml IL-10 Levels 24 Hours After Delivery |
15.22; 16.77 | — |
| PRIMARY Umbilical Cord Cytokine of pg/ml IL-10 Levels at Birth |
1; 1.5 | — |
Eligibility Criteria
Inclusion Criteria
- Age>18
- Singleton pregnancy with no known fetal malformations
- Above or equal to 38 weeks of pregnancy
Exclusion Criteria
- Systemic medical illnesses
- Chronic medications except for iron and vitamins
- Women developing fever > 380C
- Women with history of delivery of children with cerebral palsy
- History of infertility
- Premature contractions
Data sourced from ClinicalTrials.gov (NCT00361712). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.