Phase 2 Completed N=13 Randomized Double-blind Basic Science

Effect of Baclofen on Marijuana Withdrawal and Relapse

Marijuana Dependence

Source: ClinicalTrials.gov NCT00373295 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2017

Primary outcomePrimary: Measure of Relapse: Change in Money Spent Between Baseline and Relapse Phase — 7.15; 9.77; 7.25 dollars spent on marijuana

Summary

The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.

Outcome Measures

Outcome	Result	p-value
PRIMARY Measure of Relapse: Change in Money Spent Between Baseline and Relapse Phase	7.15; 9.77; 7.25	—

Eligibility Criteria

Inclusion Criteria

Current marijuana use: average of 3 marijuana cigarettes at least 4 times per week for the past 4 weeks
Able to perform study procedures
21-45 years of age
Women practicing an effective form of birth control (condoms, diaphragm, birth control pill, IUD)

Exclusion Criteria

Current, repeated illicit drug use (other than marijuana)
Presence of significant medical illness(e.g., diabetes, cardiovascular disease, hypertension, examination, laboratory clinically significant laboratory abnormalities)
History of heart disease
Request for drug treatment
Current parole or probation
Pregnancy or current lactation
Recent history of significant violent behavior
Major current Axis I psychopathology(e.g., major depressive disorder, bipolar disorder, suicide risk, schizophrenia)
Current use of any prescription or over-the-counter medication

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00373295). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.