Phase 1
N=36
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks
Marijuana Use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT00373399 ↗Enrolled (actual)
36
Serious AEs
0.0%
Results posted
Oct 2018
Primary outcome: Primary: Change From Baseline in Iowa Gambling Task Scores [Objective Measure of Decision Making] — 3.7; 10.1; 4.4 mean number of cards
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- Inactive Marijuana (0% THC) (Drug); Low THC marijuana (1.8 %THC) (Drug); High THC marijuana (3.9% THC) (Drug)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- New York State Psychiatric Institute
- Primary completion
- Mar 2008
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in Iowa Gambling Task Scores [Objective Measure of Decision Making] |
3.7; 10.1; 4.4 | — |
Summary
The purpose of this study is to investigate the effects of smoked marijuana on both risk taking and decision making tasks.
Eligibility Criteria
Inclusion Criteria
- Current marijuana use
- 21-45 years of age
- Practicing an effective form of birth control
- Not seeking treatment for marijuana use
Exclusion Criteria
- Current, repeated illicit drug use other than marijuana
- Presence of significant medical illness (e.g., diabetes, cardiovascular disease, hypertension)
- Laboratory tests outside normal limits that are clinically unacceptable to the study physician (BP > 140/90; hematocrit < 34 for women, < 36 for men)
- Significant adverse reaction to marijuana
- Current parole or probation
- Pregnancy or current lactation
- Recent history of significant violent behavior
- Major current Axis I psychopathology (e.g., mood disorder with functional impairment or suicide risk, anxiety disorder, schizophrenia
- History of heart disease
- Current use of any over-the-counter or prescription medication from which the volunteer cannot be withdrawn
Data sourced from ClinicalTrials.gov (NCT00373399). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.