N/A
N=3,835
Red Cell Storage Duration and Outcomes in Cardiac Surgery
Blood Transfusion · Cardiac Surgery
Bottom Line
View on ClinicalTrials.gov: NCT00458783 ↗Enrolled (actual)
3,835
Serious AEs
52.1%
Results posted
Jun 2021
Primary outcome: Primary: Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. — 360; 362 Participants — p=0.08
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Prolonged RBC storage (Biological); Short RBC storage (Biological)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The Cleveland Clinic
- Primary completion
- Dec 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. |
360; 362 | 0.08 |
| PRIMARY Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events |
24; 16 | — |
| PRIMARY Effect of RBC Age on Occurrence of Neurologic Events |
19; 14 | — |
| PRIMARY Effect of RBC Age on Occurrence of Pulmonary Events. |
113; 106 | — |
| PRIMARY Effect of RBC Age on Occurrence of Renal Failure |
36; 32 | — |
| PRIMARY Effect of RBC Age on Occurrence of Infection Events |
12; 10 | — |
| PRIMARY Effect of RBC Age on Occurrence of Atrial Fibrillation |
238; 258 | — |
| PRIMARY Effect of RBC Age on Occurrence of Asystole |
29; 13 | — |
| PRIMARY Effect of RBC Age on Occurrence of Gastrointestinal Events |
33; 28 | — |
| PRIMARY Effect of RBC Age on Occurrence of Any Reoperation |
81; 69 | — |
| PRIMARY Effect of RBC Age on Occurrence of Vascular Events |
9; 7 | — |
| SECONDARY Effect of RBC Age on Intensive Care Unit (ICU) Length of Stay. |
54; 51 | 0.9 |
| SECONDARY Effect of RBC Age on Postoperative Hospital Lengths of Stay. |
9; 9 | 0.07 |
Summary
The purpose of this study is to determine whether length of storage of RBC is related to postoperative morbid outcomes in patients undergoing cardiac surgery.
Eligibility Criteria
Inclusion Criteria
- All primary and reoperative adult cardiac surgical patients undergoing cardiopulmonary bypass for coronary artery bypass grafting, coronary artery bypass grafting with a valve procedure, isolated valve procedures, ascending aortic aneurysm or dissection repair alone or combined with CABG and valve procedures
Exclusion Criteria
- Age less than 18 years
- Descending thoracic aortic aneurysm repairs
- Left or right ventricular assist devices
- Those unable to receive blood for religious reasons
Data sourced from ClinicalTrials.gov (NCT00458783). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.