N/A
N=30
Evaluation of Etomidate on Adrenal Function in Trauma Patients
Adrenal Insufficiency
Bottom Line
View on ClinicalTrials.gov: NCT00462644 ↗Enrolled (actual)
30
Serious AEs
6.7%
Results posted
Nov 2009
Primary outcome: Primary: Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- RSI sedation with etomidate/succinylcholine (Drug); RSI sedation with fentanyl/midazolam/succinylcholine (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Tennessee
- Primary completion
- Aug 2006
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test |
— | — |
| PRIMARY Postintubation Cortisol (Baseline Cortisol Level) |
18.2; 27.9 | 0.022 sig |
| PRIMARY Change in Baseline Cortisol |
-12.8; 1.1 | 0.003 sig |
| PRIMARY Cortisol Level 60 Minutes After Cortisol Stimulating Test (CST) |
22.91; 39.09 | <0.001 sig |
| SECONDARY Hospital Length of Stay |
13.9; 6.4 | 0.007 sig |
| SECONDARY Intensive Care Unit (ICU) Length of Stay |
8.1; 3.0 | 0.011 sig |
| SECONDARY Ventilator Days |
6.3; 1.5 | 0.007 sig |
| SECONDARY Number of Deaths |
2; 0 | — |
Summary
Trauma patients are at increased risk for adrenal function insufficiency. A commonly used agent for rapid sequence intubation (RSI) is known to decrease adrenal function. We want to determine the incidence of adrenocortical insufficiency and its significance during the first 24 hours of resuscitation following RSI in trauma patients.
Eligibility Criteria
Inclusion Criteria
- Trauma mechanism of injury
- Patient requires rapid sequence induction for ventilatory support
Exclusion Criteria
- <18 years old
- Prisoners
- Pregnant women
- Patients with a history of adrenal insufficiency
- Patients with adrenal trauma documented by CT scan
- Patients receiving corticosteroids in the previous year
Data sourced from ClinicalTrials.gov (NCT00462644). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.