Phase 4
Completed N=22
Impact of Cholinesterase Inhibitors on Driving Ability in Healthy Older Adults
Mental Health Disorders · Geriatrics
Source: ClinicalTrials.gov NCT00482001 ↗
Enrolled (actual)
22
Serious AEs
0.0%
Results posted
May 2019
Primary outcomePrimary: Psychomotor Vigilance Test (PVT) — 302.62; 277.13 milliseconds
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The goal of the study is to assess the role of cholinesterase inhibitors in affecting the driving ability of cognitively intact seniors using driving simulators. We hypothesize that the use of a cholinesterase inhibitor for two weeks will be associated with improvement in safe driving behavior on a simulated driving task.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Psychomotor Vigilance Test (PVT) |
302.62; 277.13 | — |
| PRIMARY Attention Network Test (ANT) |
672.37; 637.58 | — |
| PRIMARY Speed Deviation |
-1.09; -2.41 | — |
| PRIMARY Deviation From Road Position |
27.54; 26.06 | — |
| PRIMARY Reaction Time to Wind Gusts |
1.69; 1.18 | — |
| PRIMARY Percentage of Time in Safe Zone |
60.95; 74.79 | — |
| PRIMARY Collisions |
0.40; 0.30 | — |
Eligibility Criteria
Inclusion Criteria
- valid Ontario driver's license
- active driver (greater than or equal to three times per week)
- written, informed consent
- lives in Toronto/Thunder Bay
- healthy
- Male between 65-75 years old
Exclusion Criteria
- cognitive impairment
- psychiatric history
- sleep disorder history
- substance abuse
- neurological history
- medical illness
- ophthalmological disease
- psychoactive medications
- contra-indications to Donepezil
- experience car/motion sickness
Data sourced from ClinicalTrials.gov (NCT00482001). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.