Phase 4
Completed N=201
LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)
Source: ClinicalTrials.gov NCT00496834 ↗Enrolled (actual)
201
Serious AEs
5.5%
Results posted
Dec 2010
Primary outcomePrimary: Pulse Wave Velocity (PWV) Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug — 0.28; -0.12 meters/second
Summary
The primary objective of this study is to evaluate efficacy, arterial stiffness measured by Pulse Wave Velocity (PWV) of Losartan potassium group compared to Carvedilol group after 24 weeks of treatment in patients with the essential hypertension.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pulse Wave Velocity (PWV) Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug |
0.28; -0.12 | — |
| PRIMARY PWV Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug |
0.16; -0.20 | — |
| SECONDARY Systolic Blood Pressure (SBP) Mean Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug |
-15.08; -14.81 | 0.9032 |
| SECONDARY Diastolic Blood Pressure (DBP) Mean Changes From Baseline (Visit 2) to 24 Weeks (Visit 6) After the Administration of the Study Drug |
-8.43; -7.81 | 0.6574 |
Eligibility Criteria
Inclusion Criteria
- Male or Female adults, 18 years or over
- Essential Hypertension with mean SBP (systolic blood pressure) ≥ 140 mm Hg or mean DBP (diastolic blood pressure) ≥ 90 mm Hg* when blood pressure is measured at Visit 1(week -2) and at Visit 2(week 0).
If diabetes patients, mean SBP ≥ 130 mm Hg or mean DBP ≥ 80 mm Hg (Mean of blood pressure values measured consecutively at least 2 minutes apart)
- Patient who is willing to, and is able to sign the informed consent form
Exclusion Criteria
- Patient Is Pregnant Or Breastfeeding, Or Expecting To Conceive Within The Projected Duration Of The Study
- Patient Has Known Or Suspected Secondary Hypertension Of Any Etiology
- Patient has history of malignant hypertension
- Patient has history of cerebrovascular accident (cerebral infarction) or myocardiac infarction within the last 6 months
- Patient takes antihypertensive drugs
Data sourced from ClinicalTrials.gov (NCT00496834). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.