Topical Avastin for Treatment of Corneal Neovascularization

Inclusion Criteria

• Male or female, at least 18 years of age
• Clinical stable corneal neovascularization (as defined above)
• Ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits.
• All female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries.

Exclusion Criteria

• Current or recent (≤ 1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye
• Current or recent (≤ 3 months) intravitreal drug injection to the study eye; recent (≤ 1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents
• Uncontrolled hypertension defined as systolic blood pressure of ≥ 150 mmHg or diastolic blood pressure of ≥ 90 mmHg; history of a thromboembolic event, including myocardial infarction or cerebral vascular accident
• Patients age 75 or older; history of renal abnormalities
• Recent (≤ 3 months ) or planned surgery
• History of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin, or similar anticoagulant agent)
• All female patients of childbearing potential (a female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries)
• Any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study