Phase 3
Completed N=213
Buprenorphine for Prisoners
Heroin Addiction
Source: ClinicalTrials.gov NCT00574067 ↗
Enrolled (actual)
213
Serious AEs
18.0%
Results posted
Apr 2016
Primary outcomePrimary: Number of Days of Heroin Use — 6.0; 6.4; 6.5; 4.0 days
◆ Published Evidence
Emerging
6citations · ~1 / year
Longitudinal analysis of HIV-risk behaviors of participants in a randomized trial of prison-initiated buprenorphine.
Summary
This five-year study examines the effectiveness of buprenorphine treatment provided to previously-addicted inmates(N=320; 160 males, 160 females) initiated in prison and continued in the community. The study also examines the extent to which the setting of post-release buprenorphine is provided.It is expected that participants receiving in-prison buprenorphine will have superior outcomes compared to participants who did not receive in-prison buprenorphine.
Linked Publications
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Longitudinal analysis of HIV-risk behaviors of participants in a randomized trial of prison-initiated buprenorphine.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Days of Heroin Use |
6.0; 6.4; 6.5; 4.0 | — |
| PRIMARY Drug Abuse Treatment Entry and Retention in the Community |
22; 26; 23; 11 | — |
| SECONDARY Number of Days of Cocaine Use |
1.1; 4.1; 4.7; 2.7 | — |
| SECONDARY Criminal Activity |
3.4; 5.4; 3.3; 3.2 | — |
| SECONDARY Employment Status |
30.0; 29.6; 22.3; 31.4 | — |
| SECONDARY HIV Risk Behavior Needle Sharing |
2.9; .1; 2.1; .1 | — |
| SECONDARY HIV Risk Behavior |
59.7; 36.1; 33.3; 50.4 | — |
Eligibility Criteria
Inclusion Criteria
- pre-release prison inmate with 3-6 months remaining until planned release
- history of heroin dependence(meeting DSM-IV criteria of heroin dependence at the time of incarceration and manifesting physical dependence during the year preceding incarceration
- suitability for buprenorphine treatment as determined by medical evaluation
- willingness to participate in the study
- having a Baltimore address and planning to live in Baltimore after release from prison -
Exclusion Criteria
- evidence of kidney failure
- evidence of liver failure
- history of psychosis
- having a pending parole hearing
- unadjudicated charges that could result in additional prison time or transfer to another facility -
Data sourced from ClinicalTrials.gov (NCT00574067) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.