N/A
Completed N=88
GLP1R Polymorphisms and Response to GLP1
Source: ClinicalTrials.gov NCT00588380 ↗Enrolled (actual)
88
Serious AEs
0.0%
Results posted
Dec 2011
Primary outcomePrimary: Insulin Secretion at 150-180 Minutes. — 104; 94; 81; 92 10^-9 min^-1 — p=0.11
Summary
Glucagon-like Peptide-1 (GLP-1) is an important incretin hormone which acts as a powerful insulin secretagogue. Defects in GLP-1 synthesis and secretion are thought to be part of the pathogenesis of type 2 diabetes. Furthermore GLP-1 based therapy is an important part of the therapeutic armamentarium for the treatment of type 2 diabetes. The GLP-1 receptor (GLP1R) is the principal site of action of GLP-1 and GLP-1 receptor agonists like exenatide and liraglutide. The gene coding for this receptor, GLP1R, is highly polymorphic and contains numerous non-synonymous Single Nucleotide Polymorphisms (nsSNPs) which could potentially alter response to endogenous or exogenous GLP-1 or GLP-1R agonists. Indeed there is some in vitro data to support this concept. We propose to utilize a hyperglycemic clamp to test the insulin secretory response to infused GLP-1 in healthy volunteers to determine the effect of genetic variation in GLP1R on response to GLP-1.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Insulin Secretion at 150-180 Minutes. |
104; 94; 81; 92; 219 | 0.11 |
| SECONDARY Insulin Secretion at 210-240 Minutes |
152; 133; 112; 132; 325 | 0.09 |
Eligibility Criteria
Inclusion Criteria
- Aged 18-40
- fasting glucose concentration of less than 95 mg/dl.
Exclusion Criteria
- Individuals with a BMI 40 kg/m^2
- active systemic illness
- medication that can alter gastric emptying, insulin secretion & action
- history of abdominal surgery (other than appendectomy or tubal ligation).
Data sourced from ClinicalTrials.gov (NCT00588380). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.