Phase 2
Completed N=64
Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department
Source: ClinicalTrials.gov NCT00590317 ↗Enrolled (actual)
64
Serious AEs
6.3%
Results posted
May 2014
Primary outcomePrimary: Vomiting at 0 to 120 Min. — 1; 4 number of participants exp vomiting
Summary
This study will compare the effect of prochlorperazine and ondansetron for the treatment of nausea and vomiting in the emergency department.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Vomiting at 0 to 120 Min. |
1; 4 | — |
| SECONDARY Nausea at 0 to 120 Min |
16.8; 34.3 | — |
| SECONDARY Akithisia at 0 to 120 Min |
3; 1 | — |
Eligibility Criteria
Inclusion Criteria
- Patients presenting to the ED with at least one of the following
- Nausea
- Vomiting documented in the ED
Exclusion Criteria
- Previous treatment in the ED with Ondansetron, prochlorperazine, promethazine or metaclopramide
- Patients with missed last menstrual period
- Pregnancy
- Age < 18 years old
- Treatment with antineoplastic agents within 7 days prior to randomization
- Irritable bowel syndrome
- Gastroparesis
- Suspected gastrointestinal bleed
- Suspected intestinal obstruction
- Preexisting motor disorder (Restless-leg syndrome or Parkinson's disease)
- Traumatic brain injury upon admission to ED
- Intracranial hemorrhage upon admission to ED
- Patients unable to read, write or communicate in the English language
- Patients leaving the ED against medical advice
Data sourced from ClinicalTrials.gov (NCT00590317). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.