N/A
Completed N=54
Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling
Source: ClinicalTrials.gov NCT00603720 ↗Enrolled (actual)
54
Serious AEs
0.0%
Results posted
Sep 2018
Primary outcomePrimary: Effect of NO Inhibition on Myocardial Substrate Metabolism in Humans — NA; NA; NA; NA percentage of substrate
Summary
The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Effect of NO Inhibition on Myocardial Substrate Metabolism in Humans |
NA; NA; NA; NA; NA | — |
Eligibility Criteria
Inclusion Criteria
- Between the ages of 18-35 or 60-75
- Normal glucose tolerance test
- Normal plasma fasting lipid panel (fasting total cholesterol less than 220 mg/dL)
- Normal rest/stress echocardiogram
- BMI (Body Mass Index) less than 30 kg/m2
Exclusion Criteria
- Coronary artery disease
- High blood pressure
- Current smoker
- Diabetes mellitus
- Cardiovascular disease (signs and symptoms of any kind)
- History of stroke, peripheral vascular disease, or arrhythmia
- Pregnant or breastfeeding
Data sourced from ClinicalTrials.gov (NCT00603720). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.