N/A N=87 Randomized

Stress and Marijuana Cue-elicited Craving and Reactivity

Cannabis Use Disorders

Bottom Line

View on ClinicalTrials.gov: NCT00613405 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2012

Primary outcome: Primary: Subjective Craving of Marijuana — 50.5; 52.3 Scores on a Scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Stress + cue exposure (Other); No stress + cue exposure (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Medical University of South Carolina
Primary completion: May 2009

Outcome Measures

Outcome	Result	p-value
PRIMARY Subjective Craving of Marijuana	50.5; 52.3	—
SECONDARY Physiological Assessments: Serum Cortisol, ACTH, BP, HR, and GSR	—	—
SECONDARY Feelings of Stress/Anxiety as Measured by the State-Trait Inventory (STAI)	—	—
SECONDARY Current Mood as Assessed by the Mood Form	—	—

Summary

The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.

Eligibility Criteria

Inclusion Criteria

Meets Diagnostic and Statistical Methods (DSM)-IV Criteria for Marijuana Dependence
Between the ages of 18 and 65
Must abstain from marijuana use the day of testing and other drug use three days prior to testing

Exclusion Criteria

Must not be taking any psychoactive medication, or medication that alters the hypothalamic pituitary adrenal (HPA) Axis functioning
Must not be taking any medications that alter heart rate or skin conductance monitoring
Cannot meet criteria for current major Axis I disorder (may alter response to stress)
Cannot be morbidly obese (Body Mass Index >39)
Cannot meet current abuse or dependence criteria of other substances in past 90 days
Must not have a medical condition that impacts HPA functioning (Hypertension, chronic pain, Addison's disease)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00613405). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.