Phase 4
Completed N=20
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women
Melasma
Source: ClinicalTrials.gov NCT00616239 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Dec 2013
Primary outcomePrimary: Number of Participants Showing Improvement of Melasma Based on Mexameter Readings — 18 participants
Summary
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for a total of 4 peels. The first two peels will be 20% salicylic acid and the second two peels will be with 30% salicylic acid. The purpose of the study will be to evaluate the safety and efficacy of salicylic acid combined with 4% hydroquinone versus 4% hydroquinone alone.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Showing Improvement of Melasma Based on Mexameter Readings |
18 | — |
Eligibility Criteria
Inclusion Criteria
- Hispanic women ages 18-65 years of age with moderate to severe melasma
- English and Spanish-speaking women
Exclusion Criteria
- Pregnant or breast-feeding women
- Subjects who have used 4% hydroquinone within 3 months of study start
- Subjects who have used chemical peels, microdermabrasion or facial laser treatments within 9 months of study start
Data sourced from ClinicalTrials.gov (NCT00616239). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.