N/A
N=213
An Eval of Neurocognitive Function, Oxidative Damage, and Their Association With Outcomes in METH and Cocaine Abusers.
Stimulant Dependence
Bottom Line
View on ClinicalTrials.gov: NCT00628927 ↗Enrolled (actual)
213
Serious AEs
0.0%
Results posted
Aug 2013
Primary outcome: Primary: Stroop Color-word Task — 55.4; 50.5 seconds
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Cincinnati
- Primary completion
- Oct 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Stroop Color-word Task |
55.4; 50.5 | — |
| SECONDARY Barrett Impulsiveness Scale Version 11 (BIS-11) |
66.7; 69.4 | — |
| SECONDARY Tail Length From the Comet Assay for Oxidative Damage |
17.3; 15.6; 16.5 | — |
Summary
The purpose of this study is to determine whether performance on neurocognitive measures predicts treatment outcomes in individuals with substance abuse disorders. A second purpose is to compare the risk of damage, as well as actual damage, to DNA and other cell parts in people with substance abuse disorders to that of people who do not have substance abuse disorders.
Eligibility Criteria
Inclusion Criteria (METH and/or Cocaine Dependent Group):
- be randomized into the CTN-0031 (STAGE-12) trial
- current abuse or dependence for METH and/or cocaine
- endorse METH and/or cocaine as the primary drug of choice
- able to correctly distinguish the colored stimuli on the Stoop task.
Exclusion Criteria (METH and/or Cocaine Dependent Group):
- history of stroke
- history of a seizure disorder
Inclusion Criteria (Non-METH and/or Cocaine Dependent Group):
- be 18 years of age or older
- be able to understand the study and provide written informed consent in English
Exclusion Criteria (Non-METH and/or Cocaine Dependent Group):
- history of stroke
- history of a seizure disorder
- positive urine toxicology screen
- screen positive for Major Depressive Syndrome, other Depressive Syndrome, Panic Syndrome, or other Anxiety Syndrome
- meet criteria for ADHD
- have HIV/AIDS
- history of an injury in which consciousness was lost for more than 30 minutes
- meet DSM-IV criteria for dependence (either current or lifetime) for any psychoactive substance other than nicotine or for abuse (both current and lifetime) for any psychoactive substance other than nicotine or for alcohol for which a life-time history of abuse is allowed
Data sourced from ClinicalTrials.gov (NCT00628927). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.