Phase 2 N=111 Randomized Triple-blind Other

Family History Study of Alcohol Consumption Using Memantine

Alcohol Drinking

Bottom Line

View on ClinicalTrials.gov: NCT00630955 ↗

Enrolled (actual)

111

Serious AEs

0.0%

Results posted

Mar 2014

Primary outcome: Primary: Number of Drinks Consumed on Day 7 — 5.84; 5.61; 6.21 standard drinks

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: memantine (Drug); Placebo (Drug)
Age: Adult · 21+ yrs
Sex: All
Sponsor: Yale University
Primary completion: May 2011

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Drinks Consumed on Day 7	5.84; 5.61; 6.21	—
PRIMARY Baseline-adjusted Craving (YCS)	20.2; 14.1; 21.4	—
SECONDARY Stimulation Responses to Alcohol	4.643; 4.321; 6.444	—
SECONDARY Sedation Responses to Alcohol	3.286; 3.964; 3.37	—

Summary

The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.

Eligibility Criteria

Inclusion Criteria

Ages 21-50
Able to read English at 6th grade level or higher and to complete study evaluations
Regular alcohol drinker

Exclusion Criteria

Individuals who are seeking alcohol treatment
Medical conditions that would contraindicate the use of memantine
Regular use of other substances

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00630955). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.