Phase 2
Completed N=111
Family History Study of Alcohol Consumption Using Memantine
Alcohol Drinking
Source: ClinicalTrials.gov NCT00630955 ↗
Enrolled (actual)
111
Serious AEs
0.0%
Results posted
Mar 2014
Primary outcomePrimary: Number of Drinks Consumed on Day 7 — 5.84; 5.61; 6.21 standard drinks
Summary
The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Drinks Consumed on Day 7 |
5.84; 5.61; 6.21 | — |
| PRIMARY Baseline-adjusted Craving (YCS) |
20.2; 14.1; 21.4 | — |
| SECONDARY Stimulation Responses to Alcohol |
4.643; 4.321; 6.444 | — |
| SECONDARY Sedation Responses to Alcohol |
3.286; 3.964; 3.37 | — |
Eligibility Criteria
Inclusion Criteria
- Ages 21-50
- Able to read English at 6th grade level or higher and to complete study evaluations
- Regular alcohol drinker
Exclusion Criteria
- Individuals who are seeking alcohol treatment
- Medical conditions that would contraindicate the use of memantine
- Regular use of other substances
Data sourced from ClinicalTrials.gov (NCT00630955). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.