Phase 2
Completed N=13
Long-term Metazym Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)
Late Infantile Metachromatic Leukodystrophy
Source: ClinicalTrials.gov NCT00633139 ↗
Enrolled (actual)
13
Serious AEs
53.8%
Results posted
Jun 2012
Primary outcomePrimary: Relative Changes (%) in Gross Motor Function Measurement (GMFM) — -2.98; -5.42; -5.28 Relative % change in total GMFM-88 SOT — p=0.4013
Summary
This is a single center, open-label study of patients with late infantile MLD. All patients were previous treated 26 weeks in the phase I trial (EudraCT number: 2006-005341-11, NCT00418561). All patients will be offered continuing treatment in this study and will in this protocol receive 13 infusions, whereby the patients total have had 27 infusions of Metazym. One infusion will be given every other week. After a total of 52 weeks of treatment the subjects will continue treatment in a compassionate use protocol. Safety (AE/SAE) will be monitored at every visit.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Relative Changes (%) in Gross Motor Function Measurement (GMFM) |
-2.98; -5.42; -5.28 | 0.4013 |
| PRIMARY Relative Change in Mullen's Scales of Early Learning |
-2.82; -2.97; -6.98 | 0.2750 |
| SECONDARY Change in Cerebrospinal Fluid (CSF) Sulfatide |
8.60; -1.53; -2.77 | 0.1363 |
Eligibility Criteria
Inclusion Criteria
The patients from the Phase I trial must meet the following criteria to be enrolled in the study.
- Subject's legally authorized guardian(s) must provide signed, informed consent prior to performing any study-related activities (trial-related activities are any procedures that would not have been performed during normal management of the subject)
- The subject and his/her guardian(s) must have the ability to comply with the clinical protocol
Exclusion Criteria
- Spasticity so severe to inhibit transportation
- Presence of known clinically significant cardiovascular, hepatic, pulmonary or renal disease or other medical condition that, in the opinion of the Investigator, would preclude participation in the trial
- Any other medical condition or serious intercurrent illness, or extenuating circumstance that, in the opinion of the Investigator, would preclude participation in the trial
- Use of any investigational product other than rhASA within 30 days prior to study enrolment or currently enrolled in another study which involves clinical investigations
Data sourced from ClinicalTrials.gov (NCT00633139). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.