Phase 3
Completed N=147
Corneal Collagen Cross-linking for Progressive Keratoconus
Progressive Keratoconus
Source: ClinicalTrials.gov NCT00647699 ↗
Enrolled (actual)
147
Serious AEs
2.0%
Results posted
Jul 2016
Primary outcomePrimary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -1.7; 0.6 diopters
◆ Published Evidence
Highly cited
▲ Trending
100citations · ~7 / year
Effect of topographic cone location on outcomes of corneal collagen cross-linking for keratoconus and corneal ectasia.
Summary
Prospective, randomized multicenter study to determine the safety and effectiveness of performing cornea collagen cross-linking (CXL) using riboflavin and UVA light in eyes with progressive keratoconus.
Linked Publications
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Effect of topographic cone location on outcomes of corneal collagen cross-linking for keratoconus and corneal ectasia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Change From Baseline in Maximum Keratometry (Kmax) |
-1.7; 0.6 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of keratoconus
- Documented progression over previous 24 months
- Decreased BSCVA
- Must complete all study visits
Exclusion Criteria
- Prior corneal surgery or Intacs
- History of delayed wound healing
Data sourced from ClinicalTrials.gov (NCT00647699) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.