Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension

Inclusion Criteria

• Demonstrable hypertension defined as mean sitting trough cuff blood pressure ≥ 140/100 mmHg (SeSBP ≥ 140 mmHg and SeDBP ≥ 100mmHg) or mean sitting trough cuff BP ≥ 160/90 mmHg (SeSBP ≥ 160 mmHg and SeDBP ≥ 90mmHg).
• Male or female newly diagnosed hypertensive subjects or currently on hypertension medication.
• Negative urine pregnancy test at screening
• Not lactating
• Do not plan to become pregnant during the study
• Will practice birth control throughout the study by the following: oral or patch contraceptive, injectable or implantable contraceptive medication, intrauterine device, diaphragm or female condom plus spermicide
• Non childbearing potential must be classified by one of the following criteria
• Had a hysterectomy or tubal ligation at least 6 months prior to consent
• Has been postmenopausal for a least 1 year

Exclusion Criteria

• Mean sitting trough cuff DBP 9.0%. Diabetics must have documentation of HbA1c within 6 months of the Screening Visit. Undocumented subjects must have their HbA1c assessed prior to randomization. Note: Subjects with Type I or Type II diabetes controlled with insulin, diet or oral hypoglycemic agents on a stable dose for at least 30 days may be included.
• Evidence of liver disease as indicated by ALT and AST and/or total bilirubin >3 times the upper limit of normal.
• Severe renal insufficiency defined as a creatinine clearance (based on the Cockcroft-Gault formula) of <30 mL/min.
• Clinically significant laboratory elevations at Visit 1 that compromise subject safety, based on the investigator's judgment. Consideration should take into account the potential laboratory effects of the component blinded therapies.
• Positive for any one of the following tests: hepatitis B surface antigen, hepatitis C antibody (confirmed by radio immunobinding assay, RIBA) or HIV antibody (confirmed by western blot assay).
• Subjects with malignancy during the past 2 years excluding squamous cell or basal cell carcinoma of the skin.
• Known allergy to any of the medications used in the study.
• Subjects who require or are taking any concomitant medication, which may interfere with the objectives of the study (Refer to Section 5.2 for a listing of excluded medications).
• Pregnant or lactating females.
• Current history of drug or alcohol abuse.
• A subject with any medical condition, which in the judgment of the Investigator would jeopardize the evaluation of efficacy or safety and/or constitute a significant safety risk to the subject.