Phase 3
Completed N=130
Corneal Collagen Cross-Linking for Ectasia (CXL)
Ectasia
Source: ClinicalTrials.gov NCT00674661 ↗
Enrolled (actual)
130
Serious AEs
0.8%
Results posted
Jan 2017
Primary outcomePrimary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -0.5; 0.5 diopters
◆ Published Evidence
Highly cited
▲ Trending
100citations · ~7 / year
Effect of topographic cone location on outcomes of corneal collagen cross-linking for keratoconus and corneal ectasia.
Summary
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
Linked Publications
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Effect of topographic cone location on outcomes of corneal collagen cross-linking for keratoconus and corneal ectasia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Change From Baseline in Maximum Keratometry (Kmax) |
-0.5; 0.5 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of ectasia after refractive surgery
- Documented ectasia on Pentacam or topography map
- BSCVA worse than 20/20
- Must complete all study visits
Exclusion Criteria
- History of delayed wound healing
- History of corneal melt or corneal dystrophy
Data sourced from ClinicalTrials.gov (NCT00674661) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.