N/A N=321 Randomized Treatment

Effectiveness of Extended Treatments for Drug Dependence

Cocaine Dependence

Bottom Line

View on ClinicalTrials.gov: NCT00685659 ↗

Enrolled (actual)

321

Serious AEs

0.0%

Results posted

Dec 2016

Primary outcome: Primary: Abstinence — 45; 57; 45 participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Intensive Outpatient Treatment (Other); Adaptive telephone-based counseling (Other); Adaptive telephone-based counseling plus incentives (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Pennsylvania
Primary completion: Dec 2011

Outcome Measures

Outcome	Result	p-value
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Abstinence	20; 28; 24	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Cocaine Urine Toxicology	038; 0.26; 0.35	—
PRIMARY Comparison Across Groups in Societal Costs	-1545; 1564; -191	—
PRIMARY Net Saving/Spending Comparisons Across Groups From Provider Perspective	-1545; 1222; -750	—
PRIMARY Net Comparisons of Savings and Spendings Across Groups From Societal Perspective	-1545; 838; -1497	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Cocaine Use	9.80; 6.14; 6.01	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
PRIMARY Percent Days Abstinent	84.00; 88.88; 89.66	—
SECONDARY Participation in Protocol	38.8; 67.1	—
SECONDARY HIV Sex Risk Score	2.7; 3; 2.7	—
SECONDARY HIV Sex Risk Score	2.7; 3; 2.7	—

Summary

This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence. The two interventions are predicted to produce better drug use outcomes than standard care. Furthermore, the intervention that also includes monetary incentives for continued participation is hypothesized to produce better retention and drug use outcomes than the intervention without incentives. Economic analyses will determine the cost-effectiveness and benefit-cost of the interventions relative to standard care, and to each other.

Eligibility Criteria

Inclusion Criteria

qualify for a DSM-IV lifetime diagnosis of cocaine dependence and cocaine use in 6 months prior to treatment;
initial engagement in IOP, as indicated by attendance at 4 or more sessions in the first two weeks of treatment;
18 to 75 years of age;
willingness to be randomized and participate in research.
metropolitan area residents;
able to provide the name, verified telephone number, and address of at least one contact who can provide locator information on the patient during follow-up.

Exclusion Criteria

current psychotic disorder or evidence of dementia severe enough to prevent participation in outpatient treatment;
acute medical problem requiring immediate inpatient treatment;
current participation in methadone or other forms of DA treatment, other than IOP

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00685659). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.