Phase 3
Completed N=23
Clinical Neurobiology of Serotonin and Addiction
Cocaine Dependence
Source: ClinicalTrials.gov NCT00732901 ↗
Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcomePrimary: Immediate Memory Task
◆ Published Evidence
Established
90citations · ~6 / year
Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects.
Summary
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on impulsivity and cue reactivity in human cocaine users.
Linked Publications (3)
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Relationship between attentional bias to cocaine-related stimuli and impulsivity in cocaine-dependent subjects.
-
Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity.
-
Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Immediate Memory Task |
— | — |
| SECONDARY Attentional Bias as Measured by the Cocaine Stroop Task. |
90.2; 45.9; -8.6; 37.4; 56.4; 35.4 | — |
| SECONDARY Cocaine Positive Urines |
9; 8 | — |
Eligibility Criteria
Inclusion Criteria
- Non-Drug Abusing Control Subjects: Male and female subjects age 18 to 55 who do not meet current or past DSM-IV criteria for any Axis I disorder including substance abuse or dependence.
- Cocaine Dependent Subjects: Male and female subjects age 18 to 55 who meet current DSM-IV criteria for cocaine dependence.
- Female subjects: a negative pregnancy test.
Exclusion Criteria
- Non-Drug Abusing Control Subjects:
- Current or past DSM-IV Axis I disorder
- Any serious non-psychiatric medical illness requiring ongoing medical treatment or which could affect the central nervous system.
- Positive HIV test.
- For female subjects: a positive pregnancy test or breast feeding.
- Concomitant use of prescription medications that could affect the central nervous system.
- Active suicidal ideation.
- Hamilton Depression or Anxiety Scale score greater than 15
- Cocaine Dependent Subjects:
- Current DSM-IV Axis I disorder other than substance abuse/dependence
- Current diagnosis of other substance dependence besides cocaine.
- Any serious non-psychiatric medical illness requiring ongoing medical treatment or which could affect the central nervous system.
- Positive HIV test.
- For female subjects: a positive pregnancy test or breast feeding.
- Concomitant use of prescription medications that could affect the central nervous system.
- Active suicidal ideation.
- Subjects within 14 days of discontinuing a monoamine oxidase inhibitor.
- Subjects with cardiac arrythmias.
- Subjects with known hypersensitivity to escitalopram or citalopram, or mirtazapine
- Hamilton Depression or Anxiety Scale score greater than 15.
- Current alcohol abuse or dependence.
Data sourced from ClinicalTrials.gov (NCT00732901) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.