N/A
Completed N=163
Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement
Source: ClinicalTrials.gov NCT00747643 ↗Enrolled (actual)
163
Serious AEs
0.0%
Results posted
Nov 2011
Primary outcomePrimary: Tonic Craving Score (QSU) Based on Self Reports — 3.53; 4.93 Scores on a scale
Summary
The purpose of this study was to find out how varenicline works to help people quit smoking. Varenicline, also known as Chantix™, is an U.S. Food and Drug Administration (FDA) approved medication that has been shown to help people quit smoking. This study was trying to evaluate whether varenicline would change the response to smoking and the desire for cigarettes when compared to an inactive placebo control. This was not a quit smoking treatment study, and participants were not asked or required to stop smoking while in this study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Tonic Craving Score (QSU) Based on Self Reports |
3.53; 4.93 | — |
| PRIMARY Cue-provoked Cravings |
11.18; 14.61 | — |
| SECONDARY Smoking Topography - Number of Puffs on a Cigarette |
6.05; 9.86 | — |
| SECONDARY A Measure of the Subjective Expected Value of a Cigarette |
2.46; 3.72 | — |
Eligibility Criteria
Inclusion Criteria
- 18-60 years of age
- Smoke at least 15 cigarettes daily
- Expired-air carbon monoxide (CO) > 10 ppm
- Medically eligible to receive Varenicline.
Exclusion Criteria
- Patients who are pregnant or lactating
- Who show evidence of renal dysfunction (BUN > 25 mg/dL, or creatinine > 1.3 mg/dL)
- Are using other smoking cessation medications
- Have current psychiatric disorders (i.e. major depression, manic depression, and/or psychotic episodes) as determined by the Structured Clinical Interview for DSM Disorders (SCID) (First et al., 1996), will be excluded
Data sourced from ClinicalTrials.gov (NCT00747643). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.