N/A Completed N=39 Randomized Health Services Research

Evaluation of LDL Cholesterol in Patients Switched From 10 to 5 Milligrams of Zetia (Ezetimibe)

Hypercholesterolemia

Source: ClinicalTrials.gov NCT00762229 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2013

Primary outcomePrimary: LDL Cholesterol — 103; 97 mg/dL

Summary

The purpose of this study is to compare the effect on LDL cholesterol levels of converting patients who are receiving the cholesterol absorption inhibitor Zetia at a dose of 10 milligrams to 5 milligrams, when prescribed as a split 10 milligram tablet.

Outcome Measures

Outcome	Result	p-value
PRIMARY LDL Cholesterol	103; 97	—
SECONDARY Total Cholesterol	180; 167	—

Eligibility Criteria

Inclusion Criteria

Subjects receiving ezetimibe 10 mg
Subjects who have demonstrated compliance with ezetimibe as evidenced by the following Proportions of Days Covered patterns (which represent a PDC of more than 75%):
90 day prescriptions: Filled a ezetimibe prescription within the previous 4 months
60 day prescriptions: Filled a ezetimibe prescription within the previous 2.5 months
30 day prescriptions: Filled a ezetimibe prescription within the previous 1.5 months
Patients willing and able to provide signed informed consent

Exclusion Criteria

Patients not receiving ezetimibe
Patients receiving ezetimibe 5 milligrams
Patients with a history of being titrated from ezetimibe 5 to 10 mg. Stroke,TIA, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass surgery, or major surgery within the 3 months
Cancer undergoing active treatment
Participation in any clinical study within the last 30 days
Drug addiction or alcohol abuse within the past 6 months
Patients unwilling or unable to provide informed consent
Patients with poor compliance
Women of childbearing potential

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00762229). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.