N/A
Completed N=1,518
Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections
Staphylococcal Infections
Source: ClinicalTrials.gov NCT00779246 ↗
Enrolled (actual)
1,518
Serious AEs
0.0%
Results posted
Mar 2012
Primary outcomePrimary: Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection — 9; 10 participants — p=>0.05
Summary
This pilot study in our medical intensive care unit will evaluate the clinical and cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus aureus (MRSA), compared to routine daily bathing with chlorhexidine gluconate (CHG)-impregnated cloths. Outcomes include rate of MRSA acquisition, and of other hospital-acquired infections (e.g., catheter-associated bloodstream infections).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection |
9; 10 | >0.05 |
| SECONDARY Number of Participants With Central Line Associated Bloodstream Infection |
5; 3 | — |
| SECONDARY Vancomycin Resistant Enterococcal Infection or Colonization |
7; 4 | — |
Eligibility Criteria
Inclusion Criteria
- All patients admitted to the medical intensive care unit (ICU) are eligible for inclusion
Exclusion Criteria
- Patient refusal
- Contraindication to nasal swabbing (arm 1)
- Allergy/sensitivity to chlorhexidine gluconate (CHG) (arm 2)
Data sourced from ClinicalTrials.gov (NCT00779246). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.