N/A
N=276
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
Surgical Site Infection
Bottom Line
View on ClinicalTrials.gov: NCT00801099 ↗Enrolled (actual)
276
Serious AEs
4.0%
Results posted
Dec 2008
Primary outcome: Primary: Number of Participants With Surgical Site Infections — 11 participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Amoxicillin/Clavulanic Acid (Drug)
- Age
- Pediatric, Adult, Older Adult · 15+ yrs
- Sex
- All
- Sponsor
- Swiss Tropical & Public Health Institute
- Primary completion
- Mar 2005
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Surgical Site Infections |
11 | — |
| SECONDARY Sustainability of the Intervention in This Setting |
— | — |
Summary
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting. After implementation of a standardized procedure with a single shot dose of Amoxicillin/Clavulanic Acid approximately 30 min. preoperatively the rate of SSI dropped by 80% in spite of procedural risk factors like poor hygiene etc.
Eligibility Criteria
Inclusion Criteria
- surgical patient
- clean or clean-contaminated surgery
Exclusion Criteria
- infection
- preoperative antibiotic treatment
- postoperative antibiotic treatment
- open fractures
Data sourced from ClinicalTrials.gov (NCT00801099). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.