Phase 4
Completed N=32
The Impact of Grapefruit Juice on the Response to Clopidogrel
Healthy
Source: ClinicalTrials.gov NCT00817999 ↗
Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Oct 2012
Primary outcomePrimary: % Platelet Inhibition — 23.4; 24.6; 41.2; 59 percentage of platelet inhibition
Summary
This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of grapefruit juice. It will also measure the percentage of platelet aggregation inhibition with a maintenance dose of clopidogrel (75 mg/day) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz grapefruit juice daily.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY % Platelet Inhibition |
23.4; 24.6; 41.2; 59 | — |
Eligibility Criteria
Inclusion Criteria
- Ages 19-40
- Health status confirmed by medical history and physical examination and laboratory analysis
Exclusion Criteria
- Pregnancy
- Taking routine prescription or over-the-counter prescriptions
- Taken over-the-counter analgesic/anti-inflammatory medication within two weeks of study participation
- Recently had grapefruit juice or regularly drinks grapefruit juice
Data sourced from ClinicalTrials.gov (NCT00817999). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.