N/A
Completed N=17
Phenytoin and Multidose Activated Charcoal
Phenytoin Toxicity
Source: ClinicalTrials.gov NCT00823264 ↗
Enrolled (actual)
17
Serious AEs
0.0%
Results posted
Sep 2014
Primary outcomePrimary: Time of Elimination of Phenytoin in Patients With Elevated Phenytoin Levels — 41.1; 19.3 hours — p=0.049
Summary
Phenytoin is a medicine used to treat seizures. If too much is taken, patients have ill effects including sleepiness, unsteady gait, and eye problems. The amount of drug in their system can be measured in their blood. Charcoal is a medicine that can absorb phenytoin. We want to see if giving multiple doses of charcoal will quicken the removal of phenytoin from the blood. This is theorized to occur as charcoal absorbs phenytoin from across the intestines and then is secreted in the stool. Patients will be selected to receive either charcoal in multiple doses or no charcoal and their serum levels will be drawn repeatedly to follow their level. The different groups will then be compared to see if multidose charcoal does indeed increase the elimination of phenytoin from the body.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time of Elimination of Phenytoin in Patients With Elevated Phenytoin Levels |
41.1; 19.3 | 0.049 sig |
Eligibility Criteria
Inclusion Criteria
- Phenytoin level > 30 mg/L
Exclusion Criteria
- Age < 18
- Known allergy to Activated Charcoal
- Pregnant
- Inability to take PO drugs
- Non English speaking
- Inability to give consent
- Any prisoners
Data sourced from ClinicalTrials.gov (NCT00823264). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.