Phase 3 N=103 Randomized Single-blind Treatment

Ultrasound Guided Supraclavicular Nerve Block

Local Anesthetic

Bottom Line

View on ClinicalTrials.gov: NCT00825786 ↗

Enrolled (actual)

103

Serious AEs

0.0%

Results posted

Apr 2017

Primary outcome: Primary: Duration of Analgesia. — 7.5; 10 minute — p=0.14

Study Design & Population

Study type: Interventional
Phase: Phase 3
Interventions: Ropivacaine (Drug); Mepivacaine (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: The Cleveland Clinic
Primary completion: Aug 2010

Outcome Measures

Outcome	Result	p-value
PRIMARY Duration of Analgesia.	7.5; 10	0.14
SECONDARY Time to Complete Motor Block	10; 19	0.02 sig
SECONDARY Time to Onset of First Sensory Block	0; 0	0.66
SECONDARY Maximum Verbal Response Score (VRS) With Rest	4; 4	0.60
SECONDARY Maximum Verbal Response Score (VRS) With Movement	5.5; 5	0.34
SECONDARY Duration of Analgesia	9; 11	0.15
SECONDARY Total Opioid Consumption	38; 30	0.88

Summary

This study will test the hypothesis that sequential injection of 1.5% mepivacaine followed 90 seconds later by 0.5% ropivacaine in ultrasound guided supraclavicular block provides a quicker onset and a longer duration of analgesia than an equi-dose mixture of the two local anesthetics.

Eligibility Criteria

Inclusion Criteria

Patients undergoing upper extremity procedures suitable for supraclavicular anesthesia, including but not limited to oHand surgery oForearm surgery oElbow surgery
Age between 18 and 70 years

Exclusion Criteria

Contraindications to supraclavicular block
Coagulopathy
Infection at the needle insertion site
Severe chronic obstructive pulmonary disease (COPD)
Contralateral pneumothorax or diaphragmatic paralysis
Pregnancy
Preexisting neuropathy involving the surgical limb
Routine opioid use
Inability to attain adequate ultrasound images in the supraclavicular area

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT00825786). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.