Phase 2
Completed N=51
Beta-blockade Effects on Memory for Cocaine Craving
Cocaine Dependence
Source: ClinicalTrials.gov NCT00830362 ↗
Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Nov 2012
Primary outcomePrimary: Single Item Craving Test Session Difference Scores — -25.0; -10.5 units on a scale
Summary
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Single Item Craving Test Session Difference Scores |
-25.0; -10.5 | — |
Eligibility Criteria
Inclusion Criteria
- Current cocaine dependence (within past month)
- Able to provide informed consent
- Use of birth control by female participants (barrier methods, surgical sterilization, IUD, or abstinence)
- Live within 50-mile radius of research site
- Consent to remain abstinent from all drugs of abuse (except nicotine) for 24 hours prior to inpatient admission and follow-up assessment
- Consent to random assignment to propranolol or placebo
Exclusion Criteria
- Women who are pregnant, nursing or are of childbearing potential and not practicing/using birth control
- Evidence or history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal or neurological disease
- Significant liver impairment
- History of or current psychotic disorder, current severe major depressive disorder, bipolar affective disorder or a severe anxiety disorder
- Currently taking anti-arrhythmic agents, psychostimulants or other agents known to interfere with heart rate and skin conductance monitoring
- Known or suspected hypersensitivity to propranolol
- Individuals taking medications that could adversely interact with the study medication, including, but not limited to albuterol, insulin, or significant inhibitors of CYP2D6
- Individuals with bronchial asthma or chronic obstructive pulmonary disease
Data sourced from ClinicalTrials.gov (NCT00830362). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.