N/A
N=106
Variability in Adrenergic Response
Vascular Reaction to Medications
Bottom Line
View on ClinicalTrials.gov: NCT00838695 ↗Enrolled (actual)
106
Serious AEs
0.0%
Results posted
Oct 2018
Primary outcome: Primary: ED50 After Phenylephrine — 172; 310 ng/min
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Phenylephrine (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University
- Primary completion
- Dec 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY ED50 After Phenylephrine |
172; 310 | — |
| SECONDARY Change in Blood Pressure |
23.0; 18.9; 16.9; 16.4 | — |
Summary
The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.
Eligibility Criteria
Inclusion Criteria
- Age between 18 and 40 years, inclusive.
- Subject must be willing to give written informed consent and be able to adhere to diet and study schedules.
- Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with the study evaluations.
- Subjects must have a normal or clinically acceptable physical examination and ECG.
- Clinical laboratory tests (CBC, blood chemistries, and urinalysis) must be within normal limits or clinically acceptable to the investigator.
Exclusion Criteria
- Any subject who has taken any prescription or over-the-counter drugs, other than oral contraception if female, within two weeks prior to study drug administration.
- Subjects who are presently, or were formerly, narcotic addicts or alcoholics.
- Subjects who have a clinically significant allergy/intolerance to phenylephrine.
- Females with a positive serum/urine pregnancy test at screening.
- Females who are nursing.
- Subject using sildenafil or other phosphodiesterase inhibitors.
Data sourced from ClinicalTrials.gov (NCT00838695). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.