N/A
N=101
Role of Bone in Knee Osteoarthritis (OA)
Osteoarthritis, Knee
Bottom Line
View on ClinicalTrials.gov: NCT00850538 ↗Enrolled (actual)
101
Serious AEs
0.0%
Results posted
Dec 2015
Primary outcome: Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- MRI (Radiation); Primary Total Knee Replacement (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The New England Baptist Hospital
- Primary completion
- Apr 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Viable Specimens for Genetic Analysis |
14 | — |
Summary
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions. Connective tissues including tendon, ligament, and meniscus specimens normally discarded from total joint replacements will be used for live cell harvest, and protein and gene expression analyses of tissue or cultured cells.
Eligibility Criteria
Inclusion Criteria
- subjects having primary knee replacement surgery with 1 participating surgeon at NEBH (principal investigator)
Exclusion Criteria
- subjects having a revision knee replacement instead of a primary knee replacement
- contraindications for MRI
- pregnancy
Data sourced from ClinicalTrials.gov (NCT00850538). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.