Phase 4
N=34
A Study to Evaluate the Efficacy and Tolerability of Topical Therapies for the Condition of Plaque-Type Psoriasis
Plaque-Type Psoriasis
Bottom Line
View on ClinicalTrials.gov: NCT00852761 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Oct 2011
Primary outcome: Primary: At Least a One Grade Improvement for the Target Psoriasis Lesion on the Elbow or Knee (Psoriasis Grading Scale) — 15; 14 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Olux-E Foam (Drug); Clobex lotion (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Stiefel, a GSK Company
- Primary completion
- Jun 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY At Least a One Grade Improvement for the Target Psoriasis Lesion on the Elbow or Knee (Psoriasis Grading Scale) |
15; 14 | — |
| SECONDARY At Least 1 Grade Improvement Psoriasis Grading Scale |
9; 10; 14; 14 | 0.7298 |
| SECONDARY At Least a 2 Grade Improvement Psoriasis Grading Scale |
2; 1; 5; 13; 5; 13 | 0.7298 |
| SECONDARY At Least a 3 Grade Improvement Psoriasis Grading Scale |
0; 2; 0; 4 | 0.0332 sig |
| SECONDARY At Least 1 Grade Improvement in the Psoriasis Global Assessment |
6; 7; 10; 13; 14; 14 | — |
| SECONDARY At Least a 2 Grade Improvement in the Psoriasis Global Assessment |
0; 1; 6; 7; 3; 10 | 0.3101 |
| SECONDARY At Least a 3 Grade Improvement in the Psoriasis Global Assessment |
0; 0; 0; 0; 0; 3 | — |
| SECONDARY At Least 1 Grade Improvement in Subject's Global Assessment |
8; 12; 15; 16; 15; 17 | 0.1449 |
| SECONDARY At Least a 2 Grade Improvement in Subject's Global Assessment |
4; 3; 10; 11; 13; 14 | 0.6715 |
| SECONDARY At Least a 3 Grade Improvement in Subject's Global Assessment |
0; 0; 6; 8; 8; 11 | 0.4858 |
| SECONDARY Median Change in Psoriasis Grading Scale |
-1; -1; -1; -2; -1; -2 | — |
| SECONDARY Dermatology Quality of Life - Symptoms and Feelings |
1.94; 2.41; 1.06; 1.35; 0.82; 0.94 | — |
| SECONDARY Dermatology Quality of Life - Daily Activities |
0.56; 1.41; 0.53; 0.88; 0.53; 0.82 | — |
| SECONDARY Dermatology Quality of Life - Leisure |
0.5; 0.94; 0.47; 0.41; 0.35; 0.24 | — |
| SECONDARY Dermatology Quality of Life - Work and School |
0.13; 0.24; 0.06; 0.12; 0.06; 0.06 | — |
| SECONDARY Dermatology Quality of Life - Personal Relationships |
0.33; 0.41; 0.25; 0.29; 0.18; 0.12 | — |
| SECONDARY Dermatology Quality of Life - Treatment |
0.31; 0.35; 0.29; 0.24; 0.18; 0.24 | — |
| SECONDARY Total Dermatology Life Quality Index (DLQI) Score |
3.75; 5.76; 2.65; 3.29; 2.12; 2.41 | — |
| SECONDARY Dermatology Life Quality Index (DLQI) Categories |
5; 4; 6; 4; 5; 7 | — |
Summary
The purpose of the study is to determine the efficacy and safety of two different forms of a topical steroid (clobetasol propionate) in patients with plaque-type psoriasis.
Eligibility Criteria
Inclusion Criteria
- Body surface area (BSA) affected with psoriasis between 4% and 20% .
- Target lesion of at least 2 cm² on the elbow and/or knee, with a score of 2 or 3 on the Psoriasis Grading Scale for Target Lesion.
- Elbow and/or knee plaque-type psoriasis with a Psoriasis Global Assessment of mild or moderate (2 or 3).
- Definitive diagnosis of elbow and/or knee plaque-type psoriasis.
- Capable of understanding and willing to provide a signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol-specific procedures were performed.
- Male or female, 18 years of age or older at the time that the consent form was signed.
- Able to complete the study and comply with study instructions.
- Female subjects of childbearing potential must have had a negative pregnancy test. Sexually active women of childbearing potential participating in the study must have been using a medically acceptable form of contraception.
Exclusion Criteria
- Use of any emollient applied to psoriasis plaques treated with the study medication during the study.
- Other serious skin disorder or any chronic medical condition that is not well controlled.
- Female subjects who are pregnant, trying to become pregnant or lactating.
- Any major illness within 30 days prior to the baseline visit.
- Received any investigational drug or treatment within 30 days of the baseline visit or who are scheduled to receive an investigational drug or treatment other than the study products during the study.
Data sourced from ClinicalTrials.gov (NCT00852761). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.