N/A
Completed N=14
Pharmacotoxicology of Trichloroethylene Metabolites
Congenital Lactic Acidosis
Source: ClinicalTrials.gov NCT00874276 ↗
Enrolled (actual)
14
Serious AEs
7.1%
Results posted
Jun 2013
Primary outcomePrimary: Hypothesize That Subject's Genotype Will Determine How DCA is Metabolized. — 1592; 232 Minutes — p=0.023
Summary
To establish the relationship between human MAAI haplotype and DCA and tyrosine metabolism. This aim test the postulates that MAAI haplotype determines, and thus can predict,1) dose-dependent DCA kinetics and biotransformation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Hypothesize That Subject's Genotype Will Determine How DCA is Metabolized. |
1592; 232 | 0.023 sig |
| SECONDARY Terminal Half-life (the Amount of Time Needed to Clear One-half of the Dose of Drug)for Environmental Dose 2.5 ug/kg/Day. |
65.4; 74.3 | 0.42 |
Eligibility Criteria
Inclusion Criteria
- Healthy volunteers
Exclusion Criteria
- Pregnancy
- Other medications
- Psychiatric illness on meds
- Abnormal labs
Data sourced from ClinicalTrials.gov (NCT00874276). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.