Phase 1
Completed N=30
The Efficacy of Doxazosin for Cocaine Users
Cocaine Dependence
Source: ClinicalTrials.gov NCT00880997 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcomePrimary: Cocaine Negative Urines — 10; 35; 14 percentage of cocaine-negative urines
Summary
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cocaine Negative Urines |
10; 35; 14 | — |
| SECONDARY Weeks of Abstinence |
0; 44; 7 | — |
| SECONDARY # of Participants That Completed the Study |
6; 6; 5 | — |
| SECONDARY Adverse Events |
26; 9; 23 | — |
Eligibility Criteria
Inclusion Criteria
- Meets DSM-IV diagnosis criteria for cocaine dependence, as determined by self-reported use of cocaine at least once weekly for at least 1 month prior to study entry; a positive urine test for cocaine; and a score greater than 3 on the Severity of Dependence Scale
- If female, willing to use contraception throughout the study
Exclusion Criteria
- Meets DSM-IV diagnosis criteria for dependence on any drugs other than cocaine, or tobacco
- Current major psychiatric illness, including schizophrenia, bipolar disorder, or other psychotic disorder
- Current suicidal or homicidal ideation
- Current use of a prescribed psychotropic medication that cannot be discontinued
- History of or current major medical illness, including major heart, kidney, endocrine, or liver disorder; abnormal liver function (SGOT or SGPT levels three times greater than normal); or high blood pressure or low blood pressure
- High risk factor for heart disease, seizure disorders, or any illness for which disulfiram or methadone treatment would be inadvisable
- Currently taking metronidazole or clotrimazole
- Pregnant or breastfeeding
Data sourced from ClinicalTrials.gov (NCT00880997). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.