Phase 2
N=20
A Study to Evaluate the Safety, Tolerability and Efficacy of BMN 110 in Subjects With Mucopolysaccharidosis IVA
MPS IV A
Bottom Line
View on ClinicalTrials.gov: NCT00884949 ↗Enrolled (actual)
20
Serious AEs
38.3%
Results posted
Jun 2014
Primary outcome: Primary: Subject Incidence of Treatment Emergent AEs — 18; 18; 17; 17 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- BMN 110 (Drug)
- Age
- Pediatric, Adult · 5+ yrs
- Sex
- All
- Sponsor
- BioMarin Pharmaceutical
- Primary completion
- Feb 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subject Incidence of Treatment Emergent AEs |
18; 18; 17; 17; 20; 12 | — |
| SECONDARY Change From Baseline in 6MWT |
-20.7; 16.3; 13.8; -4.8; 4.0 | — |
| SECONDARY Change From Baseline in 3MSCT |
0.3; 6.1; 7.8; 9.7; 9.7 | — |
| SECONDARY Percent Change From Baseline in uKS |
-23.2; -27.9; -40.6; -32.2 | — |
| SECONDARY Percent Change From Baseline in MVV |
9.9; 11.0; 10.5; 18.4 | — |
| SECONDARY Percent Change From Baseline in FVC |
3.4; 0.2; 10.7; 12.5 | — |
Summary
This multicenter, open-label study is designed to assess safety, dose-response using pharmacokinetic (PK) and pharmacodynamic (PD) measures, and clinical efficacy of BMN 110 in subjects between 5 and 18 years of age, diagnosed with Mucopolysaccharidosis IVA (MPS IVA).
Eligibility Criteria
Inclusion Criteria
- Documented history of reduced GALNS activity relative to the normal range of the laboratory performing the assay, or documented result of molecular genetic testing confirming diagnosis of MPS IVA.
- Willing and able to provide written, signed informed consent, or in the case of subjects under the age of 16 years, provide written assent (if required) and written informed consent by a legally authorized representative after the nature of the study has been explained, and prior to any research-related procedures.
- Between 5 and 18 years of age, inclusive.
- Sexually active subjects must be willing to use an acceptable method of contraception while participating in the study.
- Females of childbearing potential must have a negative pregnancy test at Screening and be willing to have additional pregnancy tests during the study.
- Willing to perform all study procedures as physically possible.
Exclusion Criteria
- Previous hematopoietic stem cell transplant (HSCT).
- Has known hypersensitivity to BMN 110 or its excipients.
- Pregnant or breastfeeding at Screening or planning to become pregnant (self or partner) at any time during the study.
- Use of any investigational product or investigational medical device within 30 days prior to Screening, or requirement for any investigational agent prior to completion of all scheduled study assessments.
- Concurrent disease or condition that would interfere with study participation or safety, including, but not limited to, symptomatic cervical spine instability.
- Any condition that, in the view of the Principal Investigator (PI), places the subject at high risk of poor treatment compliance or of not completing the study.
Data sourced from ClinicalTrials.gov (NCT00884949). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.