Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer

Inclusion Criteria

• Female patients >=18 years of age.
• Histologically or cytologically confirmed diagnosis of unresectable locally advanced or stage IV breast cancer.
• No more than 1 prior treatment regimen for metastatic breast cancer.
• Estrogen receptor and progesterone receptor negative (defined as =1.5 × 109/L; platelet count >=100 × 109/L; hemoglobin >=9.0 g/dL.
• Creatinine =40 mL/min (as calculated by the Cockcroft-Gault method, as follows: Female creatinine clearance = (140 - age) × (weight in kg) × 0.85 (serum creatinine × 72)
• Adequate hepatic function, defined as follows: total bilirubin = the institutional lower limit of normal (LLN).
• Women of childbearing potential must agree to use adequate contraception (per institutional standard of care) during treatment and until 6 months after the last administration of investigational products.

Exclusion Criteria

• Patients with brain metastases are not eligible.
• History of another primary cancer, with the exception of the following:
• Curatively treated in situ cervical cancer;
• Curatively resected non-melanoma skin cancer;
• Other primary solid tumor curatively treated with no known active disease present and no treatment administered for >=5 years prior to study enrollment.
• History of interstitial lung disease (e.g., pneumonitis, pulmonary fibrosis), or any evidence of interstitial lung disease on the CT scan of the chest performed at the baseline visit.
• Prior anti-EGFR antibody therapy (e.g., cetuximab), or treatment with small-molecule EGFR inhibitors (e.g., gefitinib, erlotinib, lapatinib).
• Radiotherapy 12 months after the last exposure to the drug(s).
• Major surgery within 28 days or minor surgery within 14 days of study enrollment.
• Requirement of chronic use of immunosuppressive agents (e.g., methotrexate, cyclosporine).
• Any investigational agent or therapy <=30 days prior to study enrollment.
• Uncontrolled or intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia.
• History of any medical or psychiatric condition or laboratory abnormality that, in the opinion of the investigator, may increase the risks associated with the study participation or administration of the investigational products, or that may interfere with the interpretation of the results.
• Unwillingness or inability to comply with study requirements.
• Women who are pregnant or breastfeeding.
• Patients with known human immunodeficiency virus (HIV), hepatitis C virus, and/or acute or chronic hepatitis B virus infection.